Biomarkers in aggression

Mirko Manchia, Stefano Comai, Martina Pinna, Federica Pinna, Vassilios Fanos, Eileen Denovan-Wright, Bernardo Carpiniello

Résultat de recherche: Chapter

20 Citations (Scopus)

Résumé

Aggressive behavior exerts an enormous impact on society remaining among the main causes of worldwide premature death. Effective primary interventions, relying on predictive models of aggression that show adequate sensitivity and specificity are currently lacking. One strategy to increase the accuracy and precision of prediction would be to include biological data in the predictive models. Clearly, to be included in such models, biological markers should be reliably associated with the specific trait under study (i.e., diagnostic biomarkers). Aggression, however, is phenotypically highly heterogeneous, an element that has hindered the identification of reliable biomarkers. However, current research is trying to overcome these challenges by focusing on more homogenous aggression subtypes and/or by studying large sample size of aggressive individuals. Further advance is coming by bioinformatics approaches that are allowing the integration of inter-species biological data as well as the development of predictive algorithms able to discriminate subjects on the basis of the propensity toward aggressive behavior. In this review we first present a brief summary of the available evidence on neuroimaging of aggression. We will then treat extensively the data on genetic determinants, including those from hypothesis-free genome-wide association studies (GWAS) and candidate gene studies. Transcriptomic and neurochemical biomarkers will then be reviewed, and we will dedicate a section on the role of metabolomics in aggression. Finally, we will discuss how biomarkers can inform the development of new pharmacological tools as well as increase the efficacy of preventive strategies.

Langue d'origineEnglish
Titre de la publication principaleAdvances in Clinical Chemistry
ÉditeursGregory S. Makowski
Maison d'éditionAcademic Press Inc.
Pages169-237
Nombre de pages69
ISBN (imprimé)9780128207994
DOI
Statut de publicationPublished - 2019

Séries de publication

PrénomAdvances in Clinical Chemistry
Volume93
ISSN (imprimé)0065-2423
ISSN (électronique)2162-9471

Note bibliographique

Publisher Copyright:
© 2019 Elsevier Inc.

ASJC Scopus Subject Areas

  • General Chemistry
  • Clinical Biochemistry

PubMed: MeSH publication types

  • Journal Article
  • Review

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