Biosynthesis and trafficking of seven transmembrane receptor signalling complexes

Denis J. Dupré; Terence E. Hébert

doi:10.1016/j.cellsig.2006.03.009

Biosynthesis and trafficking of seven transmembrane receptor signalling complexes

Denis J. Dupré, Terence E. Hébert

Résultat de recherche: Review article › examen par les pairs

52 Citations (Scopus)

Résumé

Recent studies have shown that 7-transmembrane receptors (7TM-Rs), their associated signalling molecules and scaffolding proteins are often constitutively associated under basal conditions. These studies highlight that receptor ontogeny and trafficking are likely to play key roles in the determination of both signalling specificity and efficacy. This review highlights information about how 7TM-Rs and their associated signalling molecules are trafficked to the cell surface as well as other intracellular destinations.

Langue d'origine	English
Pages (de-à)	1549-1559
Nombre de pages	11
Journal	Cellular Signalling
Volume	18
Numéro de publication	10
DOI	https://doi.org/10.1016/j.cellsig.2006.03.009
Statut de publication	Published - oct. 2006
Publié à l'externe	Oui

Note bibliographique

Funding Information:
We apologize to numerous colleagues whose work could not be cited due to space constraints. T.E.H. is a MacDonald Scholar of the Heart and Stroke Foundation of Canada and holds a senior scholarship from the Fond de Recherche en Santé du Québec. D.J.D. holds a postdoctoral fellowship from the Heart and Stroke Foundation of Canada. We thank Victor Rebois for helpful discussions especially with regard to Table 1 . Raphaëlle Dupré and Madeleine Hébert are also acknowledged by D.J.D. and T.E.H. for moral support and encouragement.

ASJC Scopus Subject Areas

Cell Biology

Accès au document

10.1016/j.cellsig.2006.03.009

Autres fichiers et liens

Citer

@article{ea26f378239d4ece9a397571c7c3041b,

title = "Biosynthesis and trafficking of seven transmembrane receptor signalling complexes",

abstract = "Recent studies have shown that 7-transmembrane receptors (7TM-Rs), their associated signalling molecules and scaffolding proteins are often constitutively associated under basal conditions. These studies highlight that receptor ontogeny and trafficking are likely to play key roles in the determination of both signalling specificity and efficacy. This review highlights information about how 7TM-Rs and their associated signalling molecules are trafficked to the cell surface as well as other intracellular destinations.",

author = "Dupr{\'e}, {Denis J.} and H{\'e}bert, {Terence E.}",

note = "Funding Information: We apologize to numerous colleagues whose work could not be cited due to space constraints. T.E.H. is a MacDonald Scholar of the Heart and Stroke Foundation of Canada and holds a senior scholarship from the Fond de Recherche en Sant{\'e} du Qu{\'e}bec. D.J.D. holds a postdoctoral fellowship from the Heart and Stroke Foundation of Canada. We thank Victor Rebois for helpful discussions especially with regard to Table 1 . Rapha{\"e}lle Dupr{\'e} and Madeleine H{\'e}bert are also acknowledged by D.J.D. and T.E.H. for moral support and encouragement.",

year = "2006",

month = oct,

doi = "10.1016/j.cellsig.2006.03.009",

language = "English",

volume = "18",

pages = "1549--1559",

journal = "Cellular Signalling",

issn = "0898-6568",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Biosynthesis and trafficking of seven transmembrane receptor signalling complexes

AU - Dupré, Denis J.

AU - Hébert, Terence E.

N1 - Funding Information: We apologize to numerous colleagues whose work could not be cited due to space constraints. T.E.H. is a MacDonald Scholar of the Heart and Stroke Foundation of Canada and holds a senior scholarship from the Fond de Recherche en Santé du Québec. D.J.D. holds a postdoctoral fellowship from the Heart and Stroke Foundation of Canada. We thank Victor Rebois for helpful discussions especially with regard to Table 1 . Raphaëlle Dupré and Madeleine Hébert are also acknowledged by D.J.D. and T.E.H. for moral support and encouragement.

PY - 2006/10

Y1 - 2006/10

N2 - Recent studies have shown that 7-transmembrane receptors (7TM-Rs), their associated signalling molecules and scaffolding proteins are often constitutively associated under basal conditions. These studies highlight that receptor ontogeny and trafficking are likely to play key roles in the determination of both signalling specificity and efficacy. This review highlights information about how 7TM-Rs and their associated signalling molecules are trafficked to the cell surface as well as other intracellular destinations.

AB - Recent studies have shown that 7-transmembrane receptors (7TM-Rs), their associated signalling molecules and scaffolding proteins are often constitutively associated under basal conditions. These studies highlight that receptor ontogeny and trafficking are likely to play key roles in the determination of both signalling specificity and efficacy. This review highlights information about how 7TM-Rs and their associated signalling molecules are trafficked to the cell surface as well as other intracellular destinations.

UR - http://www.scopus.com/inward/record.url?scp=33747120931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747120931&partnerID=8YFLogxK

U2 - 10.1016/j.cellsig.2006.03.009

DO - 10.1016/j.cellsig.2006.03.009

M3 - Review article

C2 - 16677801

AN - SCOPUS:33747120931

SN - 0898-6568

VL - 18

SP - 1549

EP - 1559

JO - Cellular Signalling

JF - Cellular Signalling

IS - 10

ER -

Biosynthesis and trafficking of seven transmembrane receptor signalling complexes

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer