TY - JOUR
T1 - Bone turnover markers in the management of postmenopausal osteoporosis
AU - Brown, Jacques P.
AU - Albert, Caroline
AU - Nassar, Bassam A.
AU - Adachi, Jonathan D.
AU - Cole, David
AU - Davison, K. Shawn
AU - Dooley, Kent C.
AU - Don-Wauchope, Andrew
AU - Douville, Pierre
AU - Hanley, David A.
AU - Jamal, Sophie A.
AU - Josse, Robert
AU - Kaiser, Stephanie
AU - Krahn, John
AU - Krause, Richard
AU - Kremer, Richard
AU - Lepage, Raymond
AU - Letendre, Elaine
AU - Morin, Suzanne
AU - Ooi, Daylily S.
AU - Papaioaonnou, Alexandra
AU - Ste-Marie, Louis Georges
N1 - Funding Information:
This project was a result of an unrestricted grant from Osteoporosis Canada. The funding source had no role in the development of these recommendations.
PY - 2009/7
Y1 - 2009/7
N2 - Osteoporosis is the most common cause of fragility fractures. Bone remodelling is essential for repairing damaged areas within bone to preserve bone strength and for assisting in mineral homeostases. In young adults, bone remodelling is usually balanced with approximately as much bone replaced as is removed during each remodelling cycle. However, when remodelling becomes accelerated in combination with an imbalance that favours bone resorption over formation, such as during menopause, precipitous losses in bone mass occur. Bone turnover markers (BTMs) measure the rate of bone remodelling allowing for a dynamic assessment of skeletal status and hold promise in identifying those at highest risk of rapid bone loss and subsequent fracture. Further, the use of BTMs to monitor individuals administered osteoporosis therapy is attractive as monitoring anti-fracture efficacy with bone mineral density has significant limitations. This review details remodelling biology, pre-analytical and analytical sources of variability for BTMs, describes the most commonly used resorption and formation markers, and offers some guidelines for their use and interpretation in the laboratory and the clinic.
AB - Osteoporosis is the most common cause of fragility fractures. Bone remodelling is essential for repairing damaged areas within bone to preserve bone strength and for assisting in mineral homeostases. In young adults, bone remodelling is usually balanced with approximately as much bone replaced as is removed during each remodelling cycle. However, when remodelling becomes accelerated in combination with an imbalance that favours bone resorption over formation, such as during menopause, precipitous losses in bone mass occur. Bone turnover markers (BTMs) measure the rate of bone remodelling allowing for a dynamic assessment of skeletal status and hold promise in identifying those at highest risk of rapid bone loss and subsequent fracture. Further, the use of BTMs to monitor individuals administered osteoporosis therapy is attractive as monitoring anti-fracture efficacy with bone mineral density has significant limitations. This review details remodelling biology, pre-analytical and analytical sources of variability for BTMs, describes the most commonly used resorption and formation markers, and offers some guidelines for their use and interpretation in the laboratory and the clinic.
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U2 - 10.1016/j.clinbiochem.2009.04.001
DO - 10.1016/j.clinbiochem.2009.04.001
M3 - Review article
C2 - 19362543
AN - SCOPUS:67349152809
SN - 0009-9120
VL - 42
SP - 929
EP - 942
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 10-11
ER -