TY - JOUR
T1 - Calcium and Vitamin D intake and mortality
T2 - Results from the Canadian Multicentre Osteoporosis Study (CaMos)
AU - Langsetmo, Lisa
AU - Berger, Claudie
AU - Kreiger, Nancy
AU - Kovacs, Christopher S.
AU - Hanley, David A.
AU - Jamal, Sophie A.
AU - Whiting, Susan J.
AU - Genest, Jacques
AU - Morin, Suzanne N.
AU - Hodsman, Anthony
AU - Prior, Jerilynn C.
AU - Lentle, Brian
AU - Patel, Millan S.
AU - Brown, Jacques P.
AU - Anastasiades, Tassos
AU - Towheed, Tanveer
AU - Josse, Robert G.
AU - Papaioannou, Alexandra
AU - Adachi, Jonathan D.
AU - Leslie, William D.
AU - Davison, K. Shawn
AU - Goltzman, David
AU - Tenenhouse, Alan
AU - Godmaire, Suzanne
AU - Dumont, Silvia
AU - Joyce, Carol
AU - Sheppard, Emma
AU - Kirkland, Susan
AU - Kaiser, Stephanie
AU - Stanfield, Barbara
AU - Bessette, Louis
AU - Dumont, Jeanette
AU - Matthews, Barbara
AU - Josse, Bob
AU - Murray, Tim
AU - Gardner-Bray, Barbara
AU - Pickard, Laura
AU - Olszynski, Wojciech P.
AU - Thingvold, Jola
AU - Allan, Jane
AU - Andjelic, Nerkeza
PY - 2013/7
Y1 - 2013/7
N2 - Context: Calcium and vitamin D are recommended for bone health, but there are concerns about adverse risks. Some clinical studies suggest that calcium intake may be cardioprotective, whereas others report increased risk associated with calcium supplements. Both low and high serum levels of 25-hydroxyvitamin D have been associated with increased mortality. Objective: The purpose of this study was to determine the association between total calcium and vitamin D intake and mortality and heterogeneity by source of intake. Design: The Canadian Multicentre Osteoporosis Study cohort is a population-based longitudinal cohort with a 10-year follow-up (1995-2007). Setting: This study included randomly selected community-dwelling men and women. Participants: A total of 9033 participants with nonmissing calcium and vitamin D intake data and follow-up were studied. Exposure: Total calcium intake (dairy, nondairy food, and supplements) and total vitamin D intake (milk, yogurt, and supplements) were recorded. Outcome: The outcome variable was all-cause mortality. Results: There were 1160 deaths during the 10-year period. For women only, we found a possible benefit of higher total calcium intake, with a hazard ratio of 0.95 (95% confidence interval, 0.89-1.01) per 500-mg increase in daily calcium intake and no evidence of heterogeneity by source; use of calcium supplements was also associated with reduced mortality, with hazard ratio of 0.78 (95% confidence interval, 0.66-0.92) for users vs nonusers with statistically significant reductions remaining among those with doses up to 1000 mg/d. These associations were not modified by levels of concurrent vitamin D intake. No definitive associations were found among men. Conclusions: Calcium supplements, up to 1000 mg/d, and increased dietary intake of calcium may be associated with reduced risk of mortality in women. We found no evidence of mortality benefit or harm associated with vitamin D intake.
AB - Context: Calcium and vitamin D are recommended for bone health, but there are concerns about adverse risks. Some clinical studies suggest that calcium intake may be cardioprotective, whereas others report increased risk associated with calcium supplements. Both low and high serum levels of 25-hydroxyvitamin D have been associated with increased mortality. Objective: The purpose of this study was to determine the association between total calcium and vitamin D intake and mortality and heterogeneity by source of intake. Design: The Canadian Multicentre Osteoporosis Study cohort is a population-based longitudinal cohort with a 10-year follow-up (1995-2007). Setting: This study included randomly selected community-dwelling men and women. Participants: A total of 9033 participants with nonmissing calcium and vitamin D intake data and follow-up were studied. Exposure: Total calcium intake (dairy, nondairy food, and supplements) and total vitamin D intake (milk, yogurt, and supplements) were recorded. Outcome: The outcome variable was all-cause mortality. Results: There were 1160 deaths during the 10-year period. For women only, we found a possible benefit of higher total calcium intake, with a hazard ratio of 0.95 (95% confidence interval, 0.89-1.01) per 500-mg increase in daily calcium intake and no evidence of heterogeneity by source; use of calcium supplements was also associated with reduced mortality, with hazard ratio of 0.78 (95% confidence interval, 0.66-0.92) for users vs nonusers with statistically significant reductions remaining among those with doses up to 1000 mg/d. These associations were not modified by levels of concurrent vitamin D intake. No definitive associations were found among men. Conclusions: Calcium supplements, up to 1000 mg/d, and increased dietary intake of calcium may be associated with reduced risk of mortality in women. We found no evidence of mortality benefit or harm associated with vitamin D intake.
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U2 - 10.1210/jc.2013-1516
DO - 10.1210/jc.2013-1516
M3 - Article
C2 - 23703722
AN - SCOPUS:84879965736
SN - 0021-972X
VL - 98
SP - 3010
EP - 3018
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 7
ER -
