Can network analysis shed light on predictors of lithium response in bipolar I disorder?

investigators involved in the ConLiGen collaboration

Résultat de recherche: Articleexamen par les pairs

15 Citations (Scopus)

Résumé

Objective: To undertake a large-scale clinical study of predictors of lithium (Li) response in bipolar I disorder (BD-I) and apply contemporary multivariate approaches to account for inter-relationships between putative predictors. Methods: We used network analysis to estimate the number and strength of connections between potential predictors of good Li response (measured by a new scoring algorithm for the Retrospective Assessment of Response to Lithium Scale) in 900 individuals with BD-I recruited to the Consortium of Lithium Genetics. Results: After accounting for co-associations between potential predictors, the most important factors associated with the good Li response phenotype were panic disorder, manic predominant polarity, manic first episode, age at onset between 15–32 years and family history of BD. Factors most strongly linked to poor outcome were comorbid obsessive–compulsive disorder, alcohol and/or substance misuse, and/or psychosis (symptoms or syndromes). Conclusions: Network analysis can offer important additional insights to prospective studies of predictors of Li treatment outcomes. It appears to especially help in further clarifying the role of family history of BD (i.e. its direct and indirect associations) and highlighting the positive and negative associations of different subtypes of anxiety disorders with Li response, particularly the little-known negative association between Li response and obsessive–compulsive disorder.

Langue d'origineEnglish
Pages (de-à)522-533
Nombre de pages12
JournalActa Psychiatrica Scandinavica
Volume141
Numéro de publication6
DOI
Statut de publicationPublished - juin 1 2020

Note bibliographique

Funding Information:
We are grateful to colleagues at all ConLiGen centres who input detailed clinical data into the main ConLiGen data set. Without their efforts these studies would not be possible. MA wishes to acknowledge funding from: Lindsay Family Research Fund, Dalhousie Medical Research Foundation, Genome Canada and ERANet PerMed grant.

Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

ASJC Scopus Subject Areas

  • Psychiatry and Mental health

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