CB2 and GPR55 receptors as therapeutic targets for systemic immune dysregulation

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@article{6aee5703fbf34b4c9b7bc0547c2ed529,

title = "CB2 and GPR55 receptors as therapeutic targets for systemic immune dysregulation",

abstract = "The endocannabinoid system (ECS) is involved in many physiological processes and has been suggested to play a critical role in the immune response and the central nervous system (CNS). Therefore, ECS modulation has potential therapeutic effects on immune dysfunctional disorders, such as sepsis and CNS injury-induced immunodeficiency syndrome (CIDS). In sepsis, excessive release of pro- and anti-inflammatory mediators results in multi-organ dysfunction, failure, and death. In CIDS, an acute CNS injury dysregulates a normally well-balanced interplay between CNS and the immune system, leading to increased patients' susceptibility to infections. In this review, we will discuss potential therapeutic modulation of the immune response in sepsis and CNS injury by manipulation of the ECS representing a novel target for immunotherapy.",

author = "Juan Zhou and Ian Burkovskiy and Hyewon Yang and Joel Sardinha and Christian Lehmann",

note = "Publisher Copyright: {\textcopyright} 2016 Zhou, Burkovskiy, Yang, Sardinha and Lehmann.",

year = "2016",

month = aug,

day = "22",

doi = "10.3389/fphar.2016.00264",

language = "English",

volume = "7",

journal = "Frontiers in Pharmacology",

issn = "1663-9812",

publisher = "Frontiers Media S. A.",

number = "AUG",

}

TY - JOUR

T1 - CB2 and GPR55 receptors as therapeutic targets for systemic immune dysregulation

AU - Zhou, Juan

AU - Burkovskiy, Ian

AU - Yang, Hyewon

AU - Sardinha, Joel

AU - Lehmann, Christian

PY - 2016/8/22

Y1 - 2016/8/22

N2 - The endocannabinoid system (ECS) is involved in many physiological processes and has been suggested to play a critical role in the immune response and the central nervous system (CNS). Therefore, ECS modulation has potential therapeutic effects on immune dysfunctional disorders, such as sepsis and CNS injury-induced immunodeficiency syndrome (CIDS). In sepsis, excessive release of pro- and anti-inflammatory mediators results in multi-organ dysfunction, failure, and death. In CIDS, an acute CNS injury dysregulates a normally well-balanced interplay between CNS and the immune system, leading to increased patients' susceptibility to infections. In this review, we will discuss potential therapeutic modulation of the immune response in sepsis and CNS injury by manipulation of the ECS representing a novel target for immunotherapy.

AB - The endocannabinoid system (ECS) is involved in many physiological processes and has been suggested to play a critical role in the immune response and the central nervous system (CNS). Therefore, ECS modulation has potential therapeutic effects on immune dysfunctional disorders, such as sepsis and CNS injury-induced immunodeficiency syndrome (CIDS). In sepsis, excessive release of pro- and anti-inflammatory mediators results in multi-organ dysfunction, failure, and death. In CIDS, an acute CNS injury dysregulates a normally well-balanced interplay between CNS and the immune system, leading to increased patients' susceptibility to infections. In this review, we will discuss potential therapeutic modulation of the immune response in sepsis and CNS injury by manipulation of the ECS representing a novel target for immunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=84988808466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988808466&partnerID=8YFLogxK

U2 - 10.3389/fphar.2016.00264

DO - 10.3389/fphar.2016.00264

M3 - Short survey

AN - SCOPUS:84988808466

SN - 1663-9812

VL - 7

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

IS - AUG

M1 - 264

ER -

CB2 and GPR55 receptors as therapeutic targets for systemic immune dysregulation

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