Characterization of initial microfracture defects in human condyles

Caroline D. Hoemann, Yoann Gosselin, Hongmei Chen, Jun Sun, Mark B. Hurtig, Alberto Carli, William D. Stanish

Résultat de recherche: Articleexamen par les pairs

22 Citations (Scopus)

Résumé

Microfracture (MFX) is a cartilage repair technique that depends on cell migration from marrow-rich trabecular bone cavities into the cartilage lesion. This study tested the hypothesis that MFX awls with distinct geometry generate different hole shapes and variable bone marrow access in condyles with Grade III to IV lesions. Lateral and medial condyles from total knee arthroplasty (N = 24 male and female patients, 66 ± 9 years) were systematically microfractured ex vivo to 2 and 4 mm deep and the bone holes analyzed by micro-computed tomography. Subchondral bone in lesional condyles showed different degrees of sclerosis up to 2 mm deep ("porous," sclerotic, extremely dense). MFX holes ranged from 1.1 to 2.0 mm in diameter, and retained the awl shape with evidence of slight bone elastic rebound and bone compaction lining the holes that were increased by wider awl diameter and deeper MFX. Marrow access was significantly diminished by sclerosis for all three awls, with an average marrow access varying from 70% (nonlesional bone) to 40% (extremely dense bone). This study revealed that subchondral bone sclerosis can reach a critical limit beyond which MFX creates bone compaction and fissures instead of marrow access.

Langue d'origineEnglish
Pages (de-à)347-355
Nombre de pages9
JournalJournal of Knee Surgery
Volume26
Numéro de publication5
DOI
Statut de publicationPublished - oct. 1 2013
Publié à l'externeOui

Note bibliographique

Publisher Copyright:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

ASJC Scopus Subject Areas

  • Surgery
  • Orthopedics and Sports Medicine

Empreinte numérique

Plonger dans les sujets de recherche 'Characterization of initial microfracture defects in human condyles'. Ensemble, ils forment une empreinte numérique unique.

Citer