Résumé
Neurotransmitter regulation of the siphon and adjacent mantle region of bivalves has not previously been examined. In the biofouling bivalve, Dreissena polymorpha, acetylcholine and FMRFamide both elicited contractions of siphon/mantle preparations. Hexamethonium bromide inhibited acetylcholine elicited contractions but had no effect on FMRFamide-elicited contractions. FMRFamide-like immunoreactivity and chromatographic evidence for acetylcholine were found in central ganglia and the siphon/mantle region. Extracts of siphons, gonads, and gills, separated on Sephadex G-25, also contained macromolecules larger than acetylcholine and FMRFamide that caused siphon/mantle contraction. These results demonstrate regulation of contraction by several potential neurotransmitter agents in a new bivalve preparation, the siphon/mantle.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 275-282 |
| Nombre de pages | 8 |
| Journal | Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology |
| Volume | 117 |
| Numéro de publication | 3 |
| DOI | |
| Statut de publication | Published - juill. 1997 |
Note bibliographique
Funding Information:This publication is a result of work sponsored, in part, by a Dalhousie Medical Research Foundation Picchione Visiting Scholarship and by NIH grant GM-08167 to J. L. Ram and by an NSERC (Canada) Strategic Grant to R. P. Croll. F. Baidoun was supported by a work-study grant from Wayne State University. The authors gratefully acknowledge Susan Jerrine Nichols and Detroit Edison for assistance in obtaining zebra mussels, Janette Nason for help with histology, and Douglas Rasmussen for help with chromatographic techniques.
ASJC Scopus Subject Areas
- Immunology
- Pharmacology