Chronic immune thrombocytopenic purpura in children: A survey of the canadian experience

Mark Belletrutti, Kaiser Ali, Dorothy Barnard, Victor Blanchette, Anthony Chan, Michele David, Brian Luke, Victoria Price, Bruce Ritchie, John Wu

Résultat de recherche: Articleexamen par les pairs

17 Citations (Scopus)

Résumé

BACKGROUND: Immune thrombocytopenic purpura (ITP) in children is a common pediatric bleeding disorder with heterogeneous manifestations and a natural history that is not fully understood. To better understand the natural history of chronic ITP and detect response trends and outcomes of therapy, we conducted a 10-year retrospective survey of children from age 1 to 18 years with a diagnosis of chronic ITP. RESULTS: Data on 198 patients from 8 Canadian Pediatric Hematology/Oncology centers were analyzed. The majority of patients were female (58%), and were previously diagnosed with acute (primary) ITP (85%). The age at diagnosis of chronic ITP ranged from 1.1 to 17.2 years with a mean of 8.2±4.4 years. Ninety percent of patients received some form of treatment. Untreated patients had a higher mean platelet count at diagnosis of chronic ITP (P=0.009) despite similarities in mean age at first presentation and mean duration of follow-up. Thirty-four (17%) patients underwent splenectomy. Splenectomized patients tended to be significantly older, had a lower mean platelet count at diagnosis of chronic ITP, and had a longer duration of follow-up. CONCLUSIONS: The results from this study are consistent with published reports.

Langue d'origineEnglish
Pages (de-à)95-100
Nombre de pages6
JournalJournal of Pediatric Hematology/Oncology
Volume29
Numéro de publication2
DOI
Statut de publicationPublished - févr. 2007

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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