Comparison of Bolus Versus Dual-Syringe Administration Systems on Glass Yttrium-90 Microsphere Deposition in an In Vitro Microvascular Hepatic Tumor Model

Samuel R. Miller, Shaphan R. Jernigan, Robert J. Abraham, Gregory D. Buckner

Résultat de recherche: Articleexamen par les pairs

13 Citations (Scopus)

Résumé

Purpose: To utilize an in vitro microvascular hepatic tumor model to compare the deposition characteristics of glass yttrium-90 microspheres using the dual-syringe (DS) and traditional bolus administration methods. Materials and Methods: The microvascular tumor model represented a 3.5-cm tumor in a 1,400-cm3 liver with a total hepatic flow of 160 mL/min and was dynamically perfused. A microcatheter was placed in a 2-mm artery feeding the tumor model and 2 additional nontarget arteries. Glass microspheres with a diameter of 20–30 μm were administered using 2 methods: (a) DS delivery at a concentration of 50 mg/mL in either a single, continuous 2-mL infusion or two 1-mL infusions and (b) bolus delivery (BD) of 100 mg of microspheres in a single 3-mL infusion. Results: Overall, the degree of on-target deposition of the microspheres was 85% ± 11%, with no significant differences between the administration methods. Although the distal penetration into the tumor arterioles was approximately 15 mm (from the second microvascular bifurcation of the tumor model) for all the cases, the distal peak particle counts were significantly higher for the DS delivery case (approximately 5 × 105 microspheres achieving distal deposition vs 2 × 105 for the BD case). This resulted in significantly higher deposition uniformity within the tumor model (90% for the DS delivery case vs 80% for the BD case, α = 0.05). Conclusions: The use of this new in vitro microvascular hepatic tumor model demonstrated that the administration method can affect the deposition of yttrium-90 microspheres within a tumor, with greater distal deposition and more uniform tumor coverage when the microspheres are delivered at consistent concentrations using a DS delivery device. The BD administration method was associated with less favorable deposition characteristics of the microspheres.

Langue d'origineEnglish
JournalJournal of Vascular and Interventional Radiology
DOI
Statut de publicationAccepted/In press - 2022

Note bibliographique

Funding Information:
This work was performed in part at the North Carolina State University Nanofabrication Facility, a member of the North Carolina Research Triangle Nanotechnology Network, which is supported by the National Science Foundation (Grant ECCS-1542015) as part of the National Nanotechnology Coordinated Infrastructure. This study was funded in part by ABK Biomedical Inc., which is developing products related to the research described in this paper.

Funding Information:
R.J.A. is the cofounder, a shareholder, and an employee (Chief Medical Officer) of ABK Biomedical Inc.; was involved with protocol development, data analysis, review, and editing of the manuscript; and received funding for the research conducted as well as bland and 90 Y radiopaque microspheres and microsphere delivery systems from ABK Biomedical Inc. G.D.B. received funding from ABK Biomedical Inc. to conduct this study. None of the other authors have identified a conflict of interest.

Publisher Copyright:
© 2022 SIR

ASJC Scopus Subject Areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

  • Journal Article

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