Cyclosporin a inhibits 2-chloroadenosine-induced DNA cleavage in mouse thymocytes

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Résumé

Incubation of mouse thymocytes with the adenosine analogue 2-chloroadenosine resulted in enhanced internucleosomal DNA fragmentation which could be inhibited by the immunosuppressive drug cyclosporin A. In order to be effective, cyclosporin A had to be added to thymocyte preparations at the same time as 2-chloroadenosine. Since cyclosporin A is a selective inhibitor of calcineurin, our data suggest a possible role for calcineurin as a signaling intermediate in the apoptotic pathway activated in thymocytes through adenosine receptors. However, at the present time we cannot exclude the possibility that the inhibitory effect of cyclosporin A on 2-chloroadenosine- induced apoptosis may be mediated through a calcineurin-independent process.

Langue d'origineEnglish
Pages (de-à)995-1001
Nombre de pages7
JournalInternational Journal of Immunopharmacology
Volume16
Numéro de publication12
DOI
Statut de publicationPublished - déc. 1994

Note bibliographique

Funding Information:
Acknowledgement -- This work was supported by a grant to D. W. H. from the Natural Sciences and Engineering Research Council of Canada.

ASJC Scopus Subject Areas

  • Immunology
  • Pharmacology

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