Résumé
Incubation of mouse thymocytes with the adenosine analogue 2-chloroadenosine resulted in enhanced internucleosomal DNA fragmentation which could be inhibited by the immunosuppressive drug cyclosporin A. In order to be effective, cyclosporin A had to be added to thymocyte preparations at the same time as 2-chloroadenosine. Since cyclosporin A is a selective inhibitor of calcineurin, our data suggest a possible role for calcineurin as a signaling intermediate in the apoptotic pathway activated in thymocytes through adenosine receptors. However, at the present time we cannot exclude the possibility that the inhibitory effect of cyclosporin A on 2-chloroadenosine- induced apoptosis may be mediated through a calcineurin-independent process.
Langue d'origine | English |
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Pages (de-à) | 995-1001 |
Nombre de pages | 7 |
Journal | International Journal of Immunopharmacology |
Volume | 16 |
Numéro de publication | 12 |
DOI | |
Statut de publication | Published - déc. 1994 |
Note bibliographique
Funding Information:Acknowledgement -- This work was supported by a grant to D. W. H. from the Natural Sciences and Engineering Research Council of Canada.
ASJC Scopus Subject Areas
- Immunology
- Pharmacology