Desmopressin and surgical hemostasis

Edwin W. Salzman, Eduardo Rocha, Rafael Llorens, Josè PÀramo, Thomas Hackmann, Randall D. Gascoyne, Sheldon C. Naiman, Gershon H. Growe, Samuel B. Sheps, Martin T. Schechter

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4 Citations (Scopus)

Résumé

Correction of the hemorrhagic tendency and improved surgical hemostasis in mild hemophilia and von Willebrand's disease are acknowledged actions of desmopressin acetate (1-desamino-8-D-arginine vasopressin), but its effect in acquired disorders of platelet function and in patients with presumably normal hemostatic processes is disputed. Two comparative trials in adults undergoing cardiac surgery1,2 and one in patients undergoing spinal fusion3 demonstrated that desmopressin reduced operative and postoperative blood loss, and a fourth4 reported a decrease in bleeding during cardiac operations, although not in the postoperative period. On the other hand, the trial by Hackmann et al. (Nov. 23 issue), …

Langue d'origineEnglish
Pages (de-à)1085-1086
Nombre de pages2
JournalNew England Journal of Medicine
Volume322
Numéro de publication15
DOI
Statut de publicationPublished - avr. 12 1990
Publié à l'externeOui

ASJC Scopus Subject Areas

  • General Medicine

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