TY - JOUR
T1 - Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation
AU - Schlam, Daniel
AU - Bohdanowicz, Michal
AU - Chatilialoglu, Alexandros
AU - Steinberg, Benjamin E.
AU - Ueyama, Takehiko
AU - Du, Guangwei
AU - Grinstein, Sergio
AU - Fairn, Gregory D.
PY - 2013/8/9
Y1 - 2013/8/9
N2 - Background: Cell population-based studies obscure potential phagosomal heterogeneity. Results:Weused a dynamic assay to monitor superoxide production in single phagosomes and uncovered variability inNADPH oxidase activity. Conclusion: The heterogeneity is attributable to variations in local DAG accumulation, which is controlled by DAG kinases. Significance: Heterogeneity in phagosome responsiveness could enable the survival of a fraction of invading microorganisms.
AB - Background: Cell population-based studies obscure potential phagosomal heterogeneity. Results:Weused a dynamic assay to monitor superoxide production in single phagosomes and uncovered variability inNADPH oxidase activity. Conclusion: The heterogeneity is attributable to variations in local DAG accumulation, which is controlled by DAG kinases. Significance: Heterogeneity in phagosome responsiveness could enable the survival of a fraction of invading microorganisms.
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U2 - 10.1074/jbc.M113.457606
DO - 10.1074/jbc.M113.457606
M3 - Article
C2 - 23814057
AN - SCOPUS:84881448414
SN - 0021-9258
VL - 288
SP - 23090
EP - 23104
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 32
ER -