Résumé
The social amoeba Dictyostelium discoideum has long served as a model system for studying fundamental processes in cell and developmental biology. This eukaryotic microbe is also recognized as a model organism for biomedical and human disease research since the genome encodes homologs of genes linked to human disease, such as those linked to cancer and neurodegeneration. Dictyostelium has a unique life cycle composed of a unicellular growth phase and a multicellular developmental phase that is induced by starvation. During its life cycle, Dictyostelium undergoes conserved cellular processes including, but not limited to, cell proliferation, phagocytosis, intercellular signaling, cell adhesion and motility, chemotaxis, and cell differentiation. The history of the organism, the resources available to researchers in the community, and the diverse ways that Dictyostelium is used in the contemporary research lab are discussed.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 14.1.1-14.1.19 |
| Journal | Current Protocols in Essential Laboratory Techniques |
| Volume | 15 |
| Numéro de publication | 1 |
| DOI | |
| Statut de publication | Published - nov. 1 2017 |
| Publié à l'externe | Oui |
Note bibliographique
Funding Information:This article was supported by a Trent University Research Grant (to RJH).
Publisher Copyright:
Copyright © 2017 John Wiley & Sons, Inc.
ASJC Scopus Subject Areas
- Chemistry (miscellaneous)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
