Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation

Prameet M. Sheth; Ali Danesh; Anthony Sheung; Anuradha Rebbapragada; Kamnoosh Shahabi; Colin Kovacs; Roberta Halpenny; David Tilley; Tony Mazzulli; Kelly MacDonald; David Kelvin; Rupert Kaul

doi:10.1086/498576

Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation

Prameet M. Sheth, Ali Danesh, Anthony Sheung, Anuradha Rebbapragada, Kamnoosh Shahabi, Colin Kovacs, Roberta Halpenny, David Tilley, Tony Mazzulli, Kelly MacDonald, David Kelvin, Rupert Kaul

Résultat de recherche: Article › examen par les pairs

52 Citations (Scopus)

Résumé

Semen transmission of human immunodeficiency virus (HIV) drives the global pandemic. HIV loads are generally lower in semen than in blood, but semen loads may be disproportionately high in a subgroup of men. HIV loads in semen exceeded those in blood in 9 (35%) of 26 of antiretroviral therapy-naive men, and disproportionately high shedding was strongly associated with compartmentalized semen cytomegalovirus (CMV) reactivation (odds ratio [OR], 10.5; P < .01). Overall, 17 of 26 participants were shedding CMV in semen. Semen levels of HIV and CMV were closely correlated (r = 0.5; P < .01), independently of blood HIV load and CD4⁺ T cell count. Prevention of CMV reactivation warrants further study as a possible strategy to reduce semen shedding of HIV.

Langue d'origine	English
Pages (de-à)	45-48
Nombre de pages	4
Journal	Journal of Infectious Diseases
Volume	193
Numéro de publication	1
DOI	https://doi.org/10.1086/498576
Statut de publication	Published - janv. 1 2006
Publié à l'externe	Oui

Note bibliographique

Funding Information:
Received 27 May 2005; accepted 25 July 2005; electronically published 21 November 2005. Presented in part: 2005 Keystone Conference on HIV Pathogenesis, Banff, 9–15 April 2005 (abstract 420). Potential conflicts of interest: none reported. Financial support: Ontario HIV Treatment Network (support to R.K.; Career Scientist Award to K.M.; studentship award to P.S.; postdoctoral award to A.R.); Canadian Network for Vaccines and Immunotherapeutics (support to R.K. and D.K.). R.K. holds a Canada Research Chair. Reprints or correspondence: Dr. Rupert Kaul, Clinical Science Division, University of Toronto, Medical Sciences Bldg. #6356, Toronto, ON, Canada M5S 1A8 (rupert.kaul@utoronto.ca).

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1086/498576

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title = "Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation",

abstract = "Semen transmission of human immunodeficiency virus (HIV) drives the global pandemic. HIV loads are generally lower in semen than in blood, but semen loads may be disproportionately high in a subgroup of men. HIV loads in semen exceeded those in blood in 9 (35%) of 26 of antiretroviral therapy-naive men, and disproportionately high shedding was strongly associated with compartmentalized semen cytomegalovirus (CMV) reactivation (odds ratio [OR], 10.5; P < .01). Overall, 17 of 26 participants were shedding CMV in semen. Semen levels of HIV and CMV were closely correlated (r = 0.5; P < .01), independently of blood HIV load and CD4+ T cell count. Prevention of CMV reactivation warrants further study as a possible strategy to reduce semen shedding of HIV.",

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note = "Funding Information: Received 27 May 2005; accepted 25 July 2005; electronically published 21 November 2005. Presented in part: 2005 Keystone Conference on HIV Pathogenesis, Banff, 9–15 April 2005 (abstract 420). Potential conflicts of interest: none reported. Financial support: Ontario HIV Treatment Network (support to R.K.; Career Scientist Award to K.M.; studentship award to P.S.; postdoctoral award to A.R.); Canadian Network for Vaccines and Immunotherapeutics (support to R.K. and D.K.). R.K. holds a Canada Research Chair. Reprints or correspondence: Dr. Rupert Kaul, Clinical Science Division, University of Toronto, Medical Sciences Bldg. #6356, Toronto, ON, Canada M5S 1A8 (rupert.kaul@utoronto.ca).",

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AU - Sheth, Prameet M.

AU - Danesh, Ali

AU - Sheung, Anthony

AU - Rebbapragada, Anuradha

AU - Shahabi, Kamnoosh

AU - Kovacs, Colin

AU - Halpenny, Roberta

AU - Tilley, David

AU - Mazzulli, Tony

AU - MacDonald, Kelly

AU - Kelvin, David

AU - Kaul, Rupert

N1 - Funding Information: Received 27 May 2005; accepted 25 July 2005; electronically published 21 November 2005. Presented in part: 2005 Keystone Conference on HIV Pathogenesis, Banff, 9–15 April 2005 (abstract 420). Potential conflicts of interest: none reported. Financial support: Ontario HIV Treatment Network (support to R.K.; Career Scientist Award to K.M.; studentship award to P.S.; postdoctoral award to A.R.); Canadian Network for Vaccines and Immunotherapeutics (support to R.K. and D.K.). R.K. holds a Canada Research Chair. Reprints or correspondence: Dr. Rupert Kaul, Clinical Science Division, University of Toronto, Medical Sciences Bldg. #6356, Toronto, ON, Canada M5S 1A8 (rupert.kaul@utoronto.ca).

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N2 - Semen transmission of human immunodeficiency virus (HIV) drives the global pandemic. HIV loads are generally lower in semen than in blood, but semen loads may be disproportionately high in a subgroup of men. HIV loads in semen exceeded those in blood in 9 (35%) of 26 of antiretroviral therapy-naive men, and disproportionately high shedding was strongly associated with compartmentalized semen cytomegalovirus (CMV) reactivation (odds ratio [OR], 10.5; P < .01). Overall, 17 of 26 participants were shedding CMV in semen. Semen levels of HIV and CMV were closely correlated (r = 0.5; P < .01), independently of blood HIV load and CD4+ T cell count. Prevention of CMV reactivation warrants further study as a possible strategy to reduce semen shedding of HIV.

AB - Semen transmission of human immunodeficiency virus (HIV) drives the global pandemic. HIV loads are generally lower in semen than in blood, but semen loads may be disproportionately high in a subgroup of men. HIV loads in semen exceeded those in blood in 9 (35%) of 26 of antiretroviral therapy-naive men, and disproportionately high shedding was strongly associated with compartmentalized semen cytomegalovirus (CMV) reactivation (odds ratio [OR], 10.5; P < .01). Overall, 17 of 26 participants were shedding CMV in semen. Semen levels of HIV and CMV were closely correlated (r = 0.5; P < .01), independently of blood HIV load and CD4+ T cell count. Prevention of CMV reactivation warrants further study as a possible strategy to reduce semen shedding of HIV.

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Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

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