Don et transplantation cardiaques après un décès circulatoire: évaluation d’experts issus d’un processus canadien d’établissement de consensus

Sam D. Shemie, Sylvia Torrance, Lindsay Wilson, Laura Hornby, Janet MacLean, Jim Mohr, Clay Gillrie, Mitesh V. Badiwala, Andrew Baker, Darren H. Freed, Christy Simpson, Jeanne Teitelbaum, Diana Brodrecht, Andrew Healey

Résultat de recherche: Articleexamen par les pairs

23 Citations (Scopus)

Résumé

Controlled donation after circulatory determination of death (DCD), where death is determined after cardiac arrest, has been responsible for the largest quantitative increase in Canadian organ donation and transplants, but not for heart transplants. Innovative international advances in DCD heart transplantation include direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). After death is determined, DPP involves removal and reanimation of the arrested heart on an ex situ organ perfusion system. Normothermic regional perfusion involves surgically interrupting (ligating the aortic arch vessels) brain blood flow after death determination, followed by restarting the heart and circulation in situ using extracorporeal membrane oxygenation. The objectives of this Canadian consensus building process by a multidisciplinary group of Canadian stakeholders were to review current evidence and international DCD heart experience, comparatively evaluate international protocols with existing Canadian medical, legal, and ethical practices, and to discuss implementation barriers. Review of current evidence and international experience of DCD heart donation (DPP and NRP) determined that DCD heart donation could be used to provide opportunities for more heart transplants in Canada, saving additional lives. Although candid discussion identified a number of potential barriers and challenges for implementing DCD heart donation in Canada, it was determined that DPP implementation is feasible (pending regulatory approval for the use of an ex situ perfusion device in humans) and in alignment with current medical guidelines for DCD. Nevertheless, further work is required to evaluate the consistency of NRP with current Canadian death determination policy and to ensure the absence of brain perfusion during this process.

Titre traduit de la contributionHeart donation and transplantation after circulatory determination of death: expert guidance from a Canadian consensus building process
Langue d'origineFrench
Pages (de-à)661-671
Nombre de pages11
JournalCanadian Journal of Anaesthesia
Volume68
Numéro de publication5
DOI
Statut de publicationPublished - mai 2021

Note bibliographique

Funding Information:
This meeting was supported financially by Canadian Blood Services through a contribution from Health Canada in support of developing leading practices, and Trillium Gift of Life Network. Canadian Blood Services is a national, not-for-profit charitable organization. In the domain of organ and tissue donation and transplantation, it provides national services in the development of leading practices, system performance measurement, interprovincial organ sharing registries, and public awareness and education. Canadian Blood Services is not responsible for the management or funding of any Canadian organ donation organizations or transplant programs. Canadian Blood Services receives its funding from the provincial and territorial Ministries of Health and from the federal government (through Health Canada).

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus Subject Areas

  • Anesthesiology and Pain Medicine

PubMed: MeSH publication types

  • Journal Article

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