Dopamine D1 receptor stimulation increases striatal acetylcholine release in the rat

Geert Damsma; Chui Se Tham; George S. Robertson; Hans C. Fibiger

doi:10.1016/0014-2999(90)90456-G

Dopamine D₁ receptor stimulation increases striatal acetylcholine release in the rat

Geert Damsma, Chui Se Tham, George S. Robertson, Hans C. Fibiger

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Résumé

The effect of selective D₁ receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. Another D₁ receptor agonist CY 204-283 (1 mg/kg s.c.) also produced a 75% increase in ACh output. The racemate (±)-SKF 38393 (20 mg/kg s.c.) increased ACh output by 60% and this was completely blocked by the D₁ receptor antagonist SCH 23390 (0.3 mg/kg s.c.). In contrast, administration of the D₂ receptor antagonist raclopride (1 mg/kg s.c.), 60 min after (±)-SKF 38393 (20 mg/kg s.c.), further increased ACh release. These results suggest that activation of D₁ receptors increases ACh release in vivo and that D₁ and D₂ receptors have opposing roles in the regulation of striatal ACh release.

Langue d'origine	English
Pages (de-à)	335-338
Nombre de pages	4
Journal	European Journal of Pharmacology
Volume	186
Numéro de publication	2-3
DOI	https://doi.org/10.1016/0014-2999(90)90456-G
Statut de publication	Published - sept. 21 1990
Publié à l'externe	Oui

Note bibliographique

Funding Information:
G.D. was supported, in part, by a grant from the Netherlands Organization for the Advancement of Research (NWO), G.S.R. is supported by a post-doctoral fellowship from the Canadian M.R.C. CY 208-243 was a generous gift of Sandoz, Basel and raclopride was kindly provided by Astra, Canada.

ASJC Scopus Subject Areas

Pharmacology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Accès au document

10.1016/0014-2999(90)90456-G

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title = "Dopamine D1 receptor stimulation increases striatal acetylcholine release in the rat",

abstract = "The effect of selective D1 receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. Another D1 receptor agonist CY 204-283 (1 mg/kg s.c.) also produced a 75% increase in ACh output. The racemate (±)-SKF 38393 (20 mg/kg s.c.) increased ACh output by 60% and this was completely blocked by the D1 receptor antagonist SCH 23390 (0.3 mg/kg s.c.). In contrast, administration of the D2 receptor antagonist raclopride (1 mg/kg s.c.), 60 min after (±)-SKF 38393 (20 mg/kg s.c.), further increased ACh release. These results suggest that activation of D1 receptors increases ACh release in vivo and that D1 and D2 receptors have opposing roles in the regulation of striatal ACh release.",

author = "Geert Damsma and Tham, {Chui Se} and Robertson, {George S.} and Fibiger, {Hans C.}",

note = "Funding Information: G.D. was supported, in part, by a grant from the Netherlands Organization for the Advancement of Research (NWO), G.S.R. is supported by a post-doctoral fellowship from the Canadian M.R.C. CY 208-243 was a generous gift of Sandoz, Basel and raclopride was kindly provided by Astra, Canada.",

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AU - Robertson, George S.

AU - Fibiger, Hans C.

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N2 - The effect of selective D1 receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. Another D1 receptor agonist CY 204-283 (1 mg/kg s.c.) also produced a 75% increase in ACh output. The racemate (±)-SKF 38393 (20 mg/kg s.c.) increased ACh output by 60% and this was completely blocked by the D1 receptor antagonist SCH 23390 (0.3 mg/kg s.c.). In contrast, administration of the D2 receptor antagonist raclopride (1 mg/kg s.c.), 60 min after (±)-SKF 38393 (20 mg/kg s.c.), further increased ACh release. These results suggest that activation of D1 receptors increases ACh release in vivo and that D1 and D2 receptors have opposing roles in the regulation of striatal ACh release.

AB - The effect of selective D1 receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. Another D1 receptor agonist CY 204-283 (1 mg/kg s.c.) also produced a 75% increase in ACh output. The racemate (±)-SKF 38393 (20 mg/kg s.c.) increased ACh output by 60% and this was completely blocked by the D1 receptor antagonist SCH 23390 (0.3 mg/kg s.c.). In contrast, administration of the D2 receptor antagonist raclopride (1 mg/kg s.c.), 60 min after (±)-SKF 38393 (20 mg/kg s.c.), further increased ACh release. These results suggest that activation of D1 receptors increases ACh release in vivo and that D1 and D2 receptors have opposing roles in the regulation of striatal ACh release.

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