Dopamine-receptor stimulation: Biobehavioral and biochemical consequences

Frédéric Calon; Abdallah Hadj Tahar; Pierre J. Blanchet; Marc Morissette; Richard Grondin; Martin Goulet; Jean Pierre Doucet; George S. Robertson; Eric Nestler; Thérèse Di Paolo; Paul J. Bédard

doi:10.1016/S1471-1931(00)00026-4

Dopamine-receptor stimulation: Biobehavioral and biochemical consequences

Frédéric Calon, Abdallah Hadj Tahar, Pierre J. Blanchet, Marc Morissette, Richard Grondin, Martin Goulet, Jean Pierre Doucet, George S. Robertson, Eric Nestler, Thérèse Di Paolo, Paul J. Bédard

Résultat de recherche: Review article › examen par les pairs

91 Citations (Scopus)

Résumé

The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.

Langue d'origine	English
Pages (de-à)	S92-S100
Journal	Trends in Neurosciences
Volume	23
Numéro de publication	10 SUPPL.
DOI	https://doi.org/10.1016/S1471-1931(00)00026-4
Statut de publication	Published - 2000
Publié à l'externe	Oui

Note bibliographique

Funding Information:
The authors' research was supported by grants from the Medical Research Council of Canada (MRC; P.J.B. and T.D.P.) and the Parkinson Foundation of Canada (T.D.P. and P.J.B.). F.C. holds a health professional studentship from Novartis in association with the MRC of Canada and from the Fonds de la Recherche en Sant~ du Quebec.

ASJC Scopus Subject Areas

General Neuroscience

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10.1016/S1471-1931(00)00026-4

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abstract = "The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.",

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note = "Funding Information: The authors' research was supported by grants from the Medical Research Council of Canada (MRC; P.J.B. and T.D.P.) and the Parkinson Foundation of Canada (T.D.P. and P.J.B.). F.C. holds a health professional studentship from Novartis in association with the MRC of Canada and from the Fonds de la Recherche en Sant~ du Quebec.",

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AU - Morissette, Marc

AU - Grondin, Richard

AU - Goulet, Martin

AU - Doucet, Jean Pierre

AU - Robertson, George S.

AU - Nestler, Eric

AU - Di Paolo, Thérèse

AU - Bédard, Paul J.

N1 - Funding Information: The authors' research was supported by grants from the Medical Research Council of Canada (MRC; P.J.B. and T.D.P.) and the Parkinson Foundation of Canada (T.D.P. and P.J.B.). F.C. holds a health professional studentship from Novartis in association with the MRC of Canada and from the Fonds de la Recherche en Sant~ du Quebec.

PY - 2000

Y1 - 2000

N2 - The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.

AB - The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.

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Dopamine-receptor stimulation: Biobehavioral and biochemical consequences

Résumé

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ASJC Scopus Subject Areas

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