Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section

J. Dansereau, A. K. Joshi, M. E. Helewa, T. A. Doran, I. R. Lange, E. R. Luther, D. Farine, M. L. Schulz, G. L.A. Horbay, P. Griffin, W. Wassenaar

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Résumé

OBJECTIVE: The goal of this study was to compare carbetocin, a long- acting oxytocin analog, with oxytocin in the prevention of uterine atony after cesarean section. STUDY DESIGN: We enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 μg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for uterine atony. A variable sample size, sequential design was used. RESULTS: The overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P < .05. CONCLUSIONS: Carbetocin, a new drug for the prevention of uterine atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile.

Langue d'origineEnglish
Pages (de-à)670-676
Nombre de pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume180
Numéro de publication3 I
DOI
Statut de publicationPublished - 1999
Publié à l'externeOui

Note bibliographique

Funding Information:
Supported by a clinical research grant from Ferring Inc., Canada.

ASJC Scopus Subject Areas

  • Obstetrics and Gynaecology

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