Effect of parental age at birth on the accumulation of deficits, frailty and survival in older adults

Ruth E. Hubbard; Melissa K. Andrew; Kenneth Rockwood

doi:10.1093/ageing/afp035

Effect of parental age at birth on the accumulation of deficits, frailty and survival in older adults

Ruth E. Hubbard, Melissa K. Andrew, Kenneth Rockwood

Résultat de recherche: Article › examen par les pairs

20 Citations (Scopus)

Résumé

Introduction: Parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. Methods: In the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged ≥65 using a Self-Assessed Risk Factor Questionnaire and screening interview. In this secondary analysis, 5112 participants had complete data for parental age, frailty status and 10-year survival. Parental age was divided into three groups, with cut-offs at 25 and 45 for fathers and at 25 and 40 for mothers. Frailty was defined by an index of deficits. Survival was analysed using Kaplan-Meier curves and Cox regression with analyses adjusted for subject's age, sex and age of the other parent. Results: Mean maternal age at subject's birth was 29.2y (SD 6.8) and mean paternal age 33.3y (SD 7.8). There was no effect of maternal or paternal age on survival for either sons or daughters. Similarly, there was no association between parental age and subject frailty in old age. Conclusion: We did not identify an association between parental age andfrailty or longevity in older adult participants in the CSHA.

Langue d'origine	English
Pages (de-à)	380-385
Nombre de pages	6
Journal	Age and Ageing
Volume	38
Numéro de publication	4
DOI	https://doi.org/10.1093/ageing/afp035
Statut de publication	Published - 2009

Note bibliographique

Funding Information:
The data reported in this article were collected as part of the Canadian Study of Health and Aging. The core study was funded through the Seniors’ Independence Research Program from the National Health research and Development Program (NHRDP) of Health Canada [project no. 6606-3954-MC(S)]. These analyses were supported by an operating grant from the Canadian Institutes of Health Research (CIHR MOP-150940).

Funding Information:
Professor Rockwood is also supported by the Kathryn Allen Weldon Chair in Alzheimer Research at Dalhousie University. Dr Hubbard is supported by a grant from the Peel Medical Research Trust, London.

ASJC Scopus Subject Areas

Ageing
Geriatrics and Gerontology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1093/ageing/afp035

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title = "Effect of parental age at birth on the accumulation of deficits, frailty and survival in older adults",

abstract = "Introduction: Parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. Methods: In the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged ≥65 using a Self-Assessed Risk Factor Questionnaire and screening interview. In this secondary analysis, 5112 participants had complete data for parental age, frailty status and 10-year survival. Parental age was divided into three groups, with cut-offs at 25 and 45 for fathers and at 25 and 40 for mothers. Frailty was defined by an index of deficits. Survival was analysed using Kaplan-Meier curves and Cox regression with analyses adjusted for subject's age, sex and age of the other parent. Results: Mean maternal age at subject's birth was 29.2y (SD 6.8) and mean paternal age 33.3y (SD 7.8). There was no effect of maternal or paternal age on survival for either sons or daughters. Similarly, there was no association between parental age and subject frailty in old age. Conclusion: We did not identify an association between parental age andfrailty or longevity in older adult participants in the CSHA.",

author = "Hubbard, {Ruth E.} and Andrew, {Melissa K.} and Kenneth Rockwood",

note = "Funding Information: The data reported in this article were collected as part of the Canadian Study of Health and Aging. The core study was funded through the Seniors{\textquoteright} Independence Research Program from the National Health research and Development Program (NHRDP) of Health Canada [project no. 6606-3954-MC(S)]. These analyses were supported by an operating grant from the Canadian Institutes of Health Research (CIHR MOP-150940). Funding Information: Professor Rockwood is also supported by the Kathryn Allen Weldon Chair in Alzheimer Research at Dalhousie University. Dr Hubbard is supported by a grant from the Peel Medical Research Trust, London.",

year = "2009",

doi = "10.1093/ageing/afp035",

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AU - Hubbard, Ruth E.

AU - Andrew, Melissa K.

AU - Rockwood, Kenneth

N1 - Funding Information: The data reported in this article were collected as part of the Canadian Study of Health and Aging. The core study was funded through the Seniors’ Independence Research Program from the National Health research and Development Program (NHRDP) of Health Canada [project no. 6606-3954-MC(S)]. These analyses were supported by an operating grant from the Canadian Institutes of Health Research (CIHR MOP-150940). Funding Information: Professor Rockwood is also supported by the Kathryn Allen Weldon Chair in Alzheimer Research at Dalhousie University. Dr Hubbard is supported by a grant from the Peel Medical Research Trust, London.

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N2 - Introduction: Parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. Methods: In the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged ≥65 using a Self-Assessed Risk Factor Questionnaire and screening interview. In this secondary analysis, 5112 participants had complete data for parental age, frailty status and 10-year survival. Parental age was divided into three groups, with cut-offs at 25 and 45 for fathers and at 25 and 40 for mothers. Frailty was defined by an index of deficits. Survival was analysed using Kaplan-Meier curves and Cox regression with analyses adjusted for subject's age, sex and age of the other parent. Results: Mean maternal age at subject's birth was 29.2y (SD 6.8) and mean paternal age 33.3y (SD 7.8). There was no effect of maternal or paternal age on survival for either sons or daughters. Similarly, there was no association between parental age and subject frailty in old age. Conclusion: We did not identify an association between parental age andfrailty or longevity in older adult participants in the CSHA.

AB - Introduction: Parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. Methods: In the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged ≥65 using a Self-Assessed Risk Factor Questionnaire and screening interview. In this secondary analysis, 5112 participants had complete data for parental age, frailty status and 10-year survival. Parental age was divided into three groups, with cut-offs at 25 and 45 for fathers and at 25 and 40 for mothers. Frailty was defined by an index of deficits. Survival was analysed using Kaplan-Meier curves and Cox regression with analyses adjusted for subject's age, sex and age of the other parent. Results: Mean maternal age at subject's birth was 29.2y (SD 6.8) and mean paternal age 33.3y (SD 7.8). There was no effect of maternal or paternal age on survival for either sons or daughters. Similarly, there was no association between parental age and subject frailty in old age. Conclusion: We did not identify an association between parental age andfrailty or longevity in older adult participants in the CSHA.

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Effect of parental age at birth on the accumulation of deficits, frailty and survival in older adults

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

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