Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD: A Randomized, Placebo-Controlled, Crossover Trial

Canadian Respiratory Research Network

doi:10.1016/j.chest.2021.10.020

Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD: A Randomized, Placebo-Controlled, Crossover Trial

Canadian Respiratory Research Network

Medicine

Résultat de recherche: Article › examen par les pairs

11 Citations (Scopus)

Résumé

Background: Individuals with COPD have increased sensitivity to traffic-related air pollution (TRAP) such as diesel exhaust (DE), but little is known about the acute effects of TRAP on exercise responses in COPD. Research Question: Does exposure before exercise to TRAP (DE titrated to 300 μg/m³ particulate matter < 2.5 μm in diameter [DE₃₀₀]) show greater adverse effects on exercise endurance, exertional dyspnea, and cardiorespiratory responses to exercise in participants with mild to moderate COPD compared with former smokers with normal spirometry and healthy control participants? Study Design and Methods: In this double-blind, randomized, placebo-controlled, crossover study, 11 healthy control participants, nine former smokers without COPD, and nine former smokers with COPD were separately exposed to filtered air (FA) and DE₃₀₀ for 2 h separated by a minimum of 4 weeks. Participants performed symptom-limited constant load cycling tests within 2.5 h of exposure with detailed cardiorespiratory and exertional symptom measurements. Results: A significant negative effect of TRAP on exercise endurance time was found in healthy control participants (DE₃₀₀ vs FA, 10.2 ± 8.2 min vs 12.9 ± 9.5 min, respectively; P = .03), but not in former smokers without COPD (10.1 ± 6.9 min vs 12.2 ± 8.0 min, respectively; P = .57) or former smokers with COPD (9.8 ± 6.4 min vs 8.4 ± 6.6 min, respectively; P = .31). Furthermore, significant increases in inspiratory duty cycle and absolute end-expiratory and end-inspiratory lung volumes were observed, and dyspnea ratings were elevated at select submaximal measurement times only in healthy control participants. Interpretation: Contrary to our hypothesis, it was the healthy control participants, rather than the former smokers with and without COPD, who were negatively impacted by TRAP during exercise. Trial Registry: ClinicalTrials.gov; No.: NCT02236039; URL: www.clinicaltrials.gov

Langue d'origine	English
Pages (de-à)	662-675
Nombre de pages	14
Journal	Chest
Volume	161
Numéro de publication	3
DOI	https://doi.org/10.1016/j.chest.2021.10.020
Statut de publication	Published - mars 2022

Note bibliographique

Funding Information:
FUNDING/SUPPORT: Operating funding for this study came from the Canadian Respiratory Research Network (CRRN), Canadian Lung Association (CLA), British Columbia Lung Association (BCLA), and a Canadian Institutes of Health Research (CIHR) Clinical Rehabilitation New Investigator Award. N. S. was supported by fellowships from The University of British Columbia, CLA, CRRN, and BCLA. M. H. R. was supported by the CRRN, WorkSafe BC, and the Natural Sciences and Engineering Research Council (NSERC) of Canada. M. R. S. was supported by the Michael Smith Foundation for Health Research (MSFHR) and BCLA. A. H. R. was supported by the NSERC and BCLA. J. M. L. was supported by the MSFHR Health Professional Investigator Award and the CIHR/AstraZeneca Early Career Investigator Award. C. J. R. was supported by the MSFHR. C. C. was supported by the MSFHR and the Canada Research Chairs Program. J. A. G. was supported by CIHR, MSFHR, CRRN, the Providence Health Care Research Institute and St. Paul's Hospital Foundation.

Publisher Copyright:
© 2021 American College of Chest Physicians

ASJC Scopus Subject Areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Accès au document

10.1016/j.chest.2021.10.020

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@article{cd758b6cf47848e991a447d440bf47fb,

title = "Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD: A Randomized, Placebo-Controlled, Crossover Trial",

abstract = "Background: Individuals with COPD have increased sensitivity to traffic-related air pollution (TRAP) such as diesel exhaust (DE), but little is known about the acute effects of TRAP on exercise responses in COPD. Research Question: Does exposure before exercise to TRAP (DE titrated to 300 μg/m3 particulate matter < 2.5 μm in diameter [DE300]) show greater adverse effects on exercise endurance, exertional dyspnea, and cardiorespiratory responses to exercise in participants with mild to moderate COPD compared with former smokers with normal spirometry and healthy control participants? Study Design and Methods: In this double-blind, randomized, placebo-controlled, crossover study, 11 healthy control participants, nine former smokers without COPD, and nine former smokers with COPD were separately exposed to filtered air (FA) and DE300 for 2 h separated by a minimum of 4 weeks. Participants performed symptom-limited constant load cycling tests within 2.5 h of exposure with detailed cardiorespiratory and exertional symptom measurements. Results: A significant negative effect of TRAP on exercise endurance time was found in healthy control participants (DE300 vs FA, 10.2 ± 8.2 min vs 12.9 ± 9.5 min, respectively; P = .03), but not in former smokers without COPD (10.1 ± 6.9 min vs 12.2 ± 8.0 min, respectively; P = .57) or former smokers with COPD (9.8 ± 6.4 min vs 8.4 ± 6.6 min, respectively; P = .31). Furthermore, significant increases in inspiratory duty cycle and absolute end-expiratory and end-inspiratory lung volumes were observed, and dyspnea ratings were elevated at select submaximal measurement times only in healthy control participants. Interpretation: Contrary to our hypothesis, it was the healthy control participants, rather than the former smokers with and without COPD, who were negatively impacted by TRAP during exercise. Trial Registry: ClinicalTrials.gov; No.: NCT02236039; URL: www.clinicaltrials.gov",

author = "{Canadian Respiratory Research Network} and Nafeez Syed and Ryu, {Min Hyung} and Satvir Dhillon and Schaeffer, {Michele R.} and Ramsook, {Andrew H.} and Leung, {Janice M.} and Ryerson, {Christopher J.} and Christopher Carlsten and Guenette, {Jordan A.} and Shawn Aaron and James Martin and Peter Par{\'e} and James Hogg and Jonathon Leipsic and Don Sin and Wan Tan and Jordan Guenette and Mark FitzGerald and Harvey Coxson and Mohsen Sadatsafavi and Carlo Marra and John Mayo and David Proud and Richard Leigh and Anita Kozyrskyj and Jacqueline Quail and Andrew Halayko and Marni Brownell and Grace Parraga and Parameswaran Nair and Martin Stampfli and Paul O'Byrne and Samir Gupta and Noe Zamel and Felix Ratjen and Dina Brooks and Andrea Gershon and Teresa To and Wendy Ungar and Diane Lougheed and Denis O'Donnell and Bernard Thebaud and Smita Pakhale and Dean Fergusson and Ian Graham and Jeremy Grimshaw and Katherine Vandemheen and {Van Dam}, Anne and Andrea Benedetti and Paul Hernandez",

note = "Funding Information: FUNDING/SUPPORT: Operating funding for this study came from the Canadian Respiratory Research Network (CRRN), Canadian Lung Association (CLA), British Columbia Lung Association (BCLA), and a Canadian Institutes of Health Research (CIHR) Clinical Rehabilitation New Investigator Award. N. S. was supported by fellowships from The University of British Columbia, CLA, CRRN, and BCLA. M. H. R. was supported by the CRRN, WorkSafe BC, and the Natural Sciences and Engineering Research Council (NSERC) of Canada. M. R. S. was supported by the Michael Smith Foundation for Health Research (MSFHR) and BCLA. A. H. R. was supported by the NSERC and BCLA. J. M. L. was supported by the MSFHR Health Professional Investigator Award and the CIHR/AstraZeneca Early Career Investigator Award. C. J. R. was supported by the MSFHR. C. C. was supported by the MSFHR and the Canada Research Chairs Program. J. A. G. was supported by CIHR, MSFHR, CRRN, the Providence Health Care Research Institute and St. Paul's Hospital Foundation. Publisher Copyright: {\textcopyright} 2021 American College of Chest Physicians",

year = "2022",

month = mar,

doi = "10.1016/j.chest.2021.10.020",

language = "English",

volume = "161",

pages = "662--675",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

number = "3",

}

TY - JOUR

T1 - Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD

T2 - A Randomized, Placebo-Controlled, Crossover Trial

AU - Canadian Respiratory Research Network

AU - Syed, Nafeez

AU - Ryu, Min Hyung

AU - Dhillon, Satvir

AU - Schaeffer, Michele R.

AU - Ramsook, Andrew H.

AU - Leung, Janice M.

AU - Ryerson, Christopher J.

AU - Carlsten, Christopher

AU - Guenette, Jordan A.

AU - Aaron, Shawn

AU - Martin, James

AU - Paré, Peter

AU - Hogg, James

AU - Leipsic, Jonathon

AU - Sin, Don

AU - Tan, Wan

AU - Guenette, Jordan

AU - FitzGerald, Mark

AU - Coxson, Harvey

AU - Sadatsafavi, Mohsen

AU - Marra, Carlo

AU - Mayo, John

AU - Proud, David

AU - Leigh, Richard

AU - Kozyrskyj, Anita

AU - Quail, Jacqueline

AU - Halayko, Andrew

AU - Brownell, Marni

AU - Parraga, Grace

AU - Nair, Parameswaran

AU - Stampfli, Martin

AU - O'Byrne, Paul

AU - Gupta, Samir

AU - Zamel, Noe

AU - Ratjen, Felix

AU - Brooks, Dina

AU - Gershon, Andrea

AU - To, Teresa

AU - Ungar, Wendy

AU - Lougheed, Diane

AU - O'Donnell, Denis

AU - Thebaud, Bernard

AU - Pakhale, Smita

AU - Fergusson, Dean

AU - Graham, Ian

AU - Grimshaw, Jeremy

AU - Vandemheen, Katherine

AU - Van Dam, Anne

AU - Benedetti, Andrea

AU - Hernandez, Paul

N1 - Funding Information: FUNDING/SUPPORT: Operating funding for this study came from the Canadian Respiratory Research Network (CRRN), Canadian Lung Association (CLA), British Columbia Lung Association (BCLA), and a Canadian Institutes of Health Research (CIHR) Clinical Rehabilitation New Investigator Award. N. S. was supported by fellowships from The University of British Columbia, CLA, CRRN, and BCLA. M. H. R. was supported by the CRRN, WorkSafe BC, and the Natural Sciences and Engineering Research Council (NSERC) of Canada. M. R. S. was supported by the Michael Smith Foundation for Health Research (MSFHR) and BCLA. A. H. R. was supported by the NSERC and BCLA. J. M. L. was supported by the MSFHR Health Professional Investigator Award and the CIHR/AstraZeneca Early Career Investigator Award. C. J. R. was supported by the MSFHR. C. C. was supported by the MSFHR and the Canada Research Chairs Program. J. A. G. was supported by CIHR, MSFHR, CRRN, the Providence Health Care Research Institute and St. Paul's Hospital Foundation. Publisher Copyright: © 2021 American College of Chest Physicians

PY - 2022/3

Y1 - 2022/3

N2 - Background: Individuals with COPD have increased sensitivity to traffic-related air pollution (TRAP) such as diesel exhaust (DE), but little is known about the acute effects of TRAP on exercise responses in COPD. Research Question: Does exposure before exercise to TRAP (DE titrated to 300 μg/m3 particulate matter < 2.5 μm in diameter [DE300]) show greater adverse effects on exercise endurance, exertional dyspnea, and cardiorespiratory responses to exercise in participants with mild to moderate COPD compared with former smokers with normal spirometry and healthy control participants? Study Design and Methods: In this double-blind, randomized, placebo-controlled, crossover study, 11 healthy control participants, nine former smokers without COPD, and nine former smokers with COPD were separately exposed to filtered air (FA) and DE300 for 2 h separated by a minimum of 4 weeks. Participants performed symptom-limited constant load cycling tests within 2.5 h of exposure with detailed cardiorespiratory and exertional symptom measurements. Results: A significant negative effect of TRAP on exercise endurance time was found in healthy control participants (DE300 vs FA, 10.2 ± 8.2 min vs 12.9 ± 9.5 min, respectively; P = .03), but not in former smokers without COPD (10.1 ± 6.9 min vs 12.2 ± 8.0 min, respectively; P = .57) or former smokers with COPD (9.8 ± 6.4 min vs 8.4 ± 6.6 min, respectively; P = .31). Furthermore, significant increases in inspiratory duty cycle and absolute end-expiratory and end-inspiratory lung volumes were observed, and dyspnea ratings were elevated at select submaximal measurement times only in healthy control participants. Interpretation: Contrary to our hypothesis, it was the healthy control participants, rather than the former smokers with and without COPD, who were negatively impacted by TRAP during exercise. Trial Registry: ClinicalTrials.gov; No.: NCT02236039; URL: www.clinicaltrials.gov

AB - Background: Individuals with COPD have increased sensitivity to traffic-related air pollution (TRAP) such as diesel exhaust (DE), but little is known about the acute effects of TRAP on exercise responses in COPD. Research Question: Does exposure before exercise to TRAP (DE titrated to 300 μg/m3 particulate matter < 2.5 μm in diameter [DE300]) show greater adverse effects on exercise endurance, exertional dyspnea, and cardiorespiratory responses to exercise in participants with mild to moderate COPD compared with former smokers with normal spirometry and healthy control participants? Study Design and Methods: In this double-blind, randomized, placebo-controlled, crossover study, 11 healthy control participants, nine former smokers without COPD, and nine former smokers with COPD were separately exposed to filtered air (FA) and DE300 for 2 h separated by a minimum of 4 weeks. Participants performed symptom-limited constant load cycling tests within 2.5 h of exposure with detailed cardiorespiratory and exertional symptom measurements. Results: A significant negative effect of TRAP on exercise endurance time was found in healthy control participants (DE300 vs FA, 10.2 ± 8.2 min vs 12.9 ± 9.5 min, respectively; P = .03), but not in former smokers without COPD (10.1 ± 6.9 min vs 12.2 ± 8.0 min, respectively; P = .57) or former smokers with COPD (9.8 ± 6.4 min vs 8.4 ± 6.6 min, respectively; P = .31). Furthermore, significant increases in inspiratory duty cycle and absolute end-expiratory and end-inspiratory lung volumes were observed, and dyspnea ratings were elevated at select submaximal measurement times only in healthy control participants. Interpretation: Contrary to our hypothesis, it was the healthy control participants, rather than the former smokers with and without COPD, who were negatively impacted by TRAP during exercise. Trial Registry: ClinicalTrials.gov; No.: NCT02236039; URL: www.clinicaltrials.gov

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Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD: A Randomized, Placebo-Controlled, Crossover Trial

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

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