Enhanced IgE and IgG Anti‐Melittin Antibody Formation Induced by Heparin‐Melittin Complexes in Mice

L. S. Kind; E. Allaway

doi:10.1111/j.1398-9995.1982.tb01904.x

Enhanced IgE and IgG Anti‐Melittin Antibody Formation Induced by Heparin‐Melittin Complexes in Mice

L. S. Kind, E. Allaway

Medicine

Medicine

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5 Citations (Scopus)

Résumé

It is known that heparin which is strongly anionic will precipitate in vitro with cationic proteins such as melittin, the principal constituent of bee venom. Our experiments indicate that mice immunized with complexes of melittin and heparin produced greater amounts of IgE and IgG antibody (to this protein) than did mice immunized with melittin along. It is possible that heparin released from mast cells following a bee sting could complex with melittin and enhance the allergenic properties of this molecule.

Langue d'origine	English
Pages (de-à)	225-229
Nombre de pages	5
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	37
Numéro de publication	4
DOI	https://doi.org/10.1111/j.1398-9995.1982.tb01904.x
Statut de publication	Published - mai 1982

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

PubMed: MeSH publication types

Journal Article

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10.1111/j.1398-9995.1982.tb01904.x

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abstract = "It is known that heparin which is strongly anionic will precipitate in vitro with cationic proteins such as melittin, the principal constituent of bee venom. Our experiments indicate that mice immunized with complexes of melittin and heparin produced greater amounts of IgE and IgG antibody (to this protein) than did mice immunized with melittin along. It is possible that heparin released from mast cells following a bee sting could complex with melittin and enhance the allergenic properties of this molecule.",

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year = "1982",

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AU - Allaway, E.

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N2 - It is known that heparin which is strongly anionic will precipitate in vitro with cationic proteins such as melittin, the principal constituent of bee venom. Our experiments indicate that mice immunized with complexes of melittin and heparin produced greater amounts of IgE and IgG antibody (to this protein) than did mice immunized with melittin along. It is possible that heparin released from mast cells following a bee sting could complex with melittin and enhance the allergenic properties of this molecule.

AB - It is known that heparin which is strongly anionic will precipitate in vitro with cationic proteins such as melittin, the principal constituent of bee venom. Our experiments indicate that mice immunized with complexes of melittin and heparin produced greater amounts of IgE and IgG antibody (to this protein) than did mice immunized with melittin along. It is possible that heparin released from mast cells following a bee sting could complex with melittin and enhance the allergenic properties of this molecule.

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Enhanced IgE and IgG Anti‐Melittin Antibody Formation Induced by Heparin‐Melittin Complexes in Mice

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

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