Epileptic seizures in subcortical vascular encephalopathy

A. Schreiner, B. Pohlmann-Eden, A. Schwartz, M. Hennerici

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Résumé

Cerebrovascular disease is one of the most common causes of epilepsy in the elderly. Most of the studies published relate to cortical infarction, subarachnoid, and intracranial hemorrhage, whereas the incidence of epilepsy from subcortical ischemia, i.e. deep lacunar infarctions and diffuse white matter lesions, is obscure. Therefore, we prospectively examined 18 patients with the precisely defined diagnosis of subcortical vascular encephalopathy (SVE), who were admitted to our hospital due to epileptic seizures (group A), and compared them to a similarly selected group matched for age, sex, risk factors, and neurological deficits with an equivalent severity of SVE but without seizures (group B). Subcortical lacunar infarctions were significantly more frequent in group A than group B ( 15 18 versus 4 18, p < 0.001), whereas neither the extension, degree, distribution of periventricular white matter changes, nor the presence of internal hydrocephalus, focal or diffuse cortical atrophy showed any statistical significance. However, a temporal constant theta or delta EEG focus was present in 10 18 patients in group A but only in 1 18 patients from group B (p ≤ 0.005). 10 18 patients developed epilepsy with further seizures during follow-up. The association of SVE, multiple subcortical lacunas, and temporal EEG abnormalities are suggestive for an increased risk for epileptic seizures, which is particularly important for the treatment of patients with SVE if uncertain paroxysmal episodes occur, e.g. transient ischemic attacks, seizures, or cardiac syncope.

Langue d'origineEnglish
Pages (de-à)171-177
Nombre de pages7
JournalJournal of the Neurological Sciences
Volume130
Numéro de publication2
DOI
Statut de publicationPublished - juin 1995
Publié à l'externeOui

Note bibliographique

Funding Information:
This work was in part supported by a grant from Deutsche Forschungsgemeinschaft SFB 258, K4. We thank Dr. Stephen Meairs for helpful comments and Mrs. Joyce Thompson for secretarial assistance.

ASJC Scopus Subject Areas

  • Neurology
  • Clinical Neurology

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