Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998

V. Waters; E. L. Ford-Jones; M. Petric; M. Fearon; P. Corey; R. Moineddein; L. Palmerino; R. Freeman; G. Urbshott; E. Wang; M. Petric; M. Ipp; P. Corey; R. Moineddin; L. Shane; K. Thompson; E. C.Y. Wang; A. McGeer; N. MacDonald; R. Issenman; M. Fearon; K. Siu; V. Jazmaji; J. Stubberfield; J. Urquhart; K. Wark; T. Gilder; A. Pancer; L. Landry; E. Goldenberg; L. L'Estrange; P. Franceur; A. Marshall; S. Apted; M. Bates; M. Friendly; H. Beatty; B. Kawa; E. Rea; B. Yaffe; R. Shahin; J. Tooze; M. Misetic; V. Lewis; W. Mousseau; I. Kitai; D. Weinwurm; M. Kelly; G. Berall; S. Churilla; S. Moore; L. Levin; M. Court; L. Cote; G. Large; K. Cook; P. Azzopardi; G. Bajwa; P. Wyper; S. Belton; T. Vermaat; N. Lau; J. Thompson; L. Giles; M. Levy; A. Law; R. Beaulieu; P. Perkins; B. Mater; J. L. Pound; T. Stavro-Sholdoff; H. Heurter; K. Siu; J. Nishikawa; R. Tellier; N. Davies; J. Pirie; A. Matlow; S. E. Read; S. Skull; J. Jeffery; L. Komar; C. Gillies; A. Jarvis; R. Jabbour; B. Wali; R. Teteruck; M. Seguin; D. White; M. Abraham; J. Tolkin; T. Rutledge; E. McLeod; E. King; M. Davies; S. Dempsey; M. A. Pinch; D. Thornley; F. Smaill

doi:10.1097/00006454-200009000-00007

Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998

V. Waters, E. L. Ford-Jones, M. Petric, M. Fearon, P. Corey, R. Moineddein, L. Palmerino, R. Freeman, G. Urbshott, E. Wang, M. Petric, M. Ipp, P. Corey, R. Moineddin, L. Shane, K. Thompson, E. C.Y. Wang, A. McGeer, N. MacDonald, R. IssenmanM. Fearon, K. Siu, V. Jazmaji, J. Stubberfield, J. Urquhart, K. Wark, T. Gilder, A. Pancer, L. Landry, E. Goldenberg, L. L'Estrange, P. Franceur, A. Marshall, S. Apted, M. Bates, M. Friendly, H. Beatty, B. Kawa, E. Rea, B. Yaffe, R. Shahin, J. Tooze, M. Misetic, V. Lewis, W. Mousseau, I. Kitai, D. Weinwurm, M. Kelly, G. Berall, S. Churilla, S. Moore, L. Levin, M. Court, L. Cote, G. Large, K. Cook, P. Azzopardi, G. Bajwa, P. Wyper, S. Belton, T. Vermaat, N. Lau, J. Thompson, L. Giles, M. Levy, A. Law, R. Beaulieu, P. Perkins, B. Mater, J. L. Pound, T. Stavro-Sholdoff, H. Heurter, K. Siu, J. Nishikawa, R. Tellier, N. Davies, J. Pirie, A. Matlow, S. E. Read, S. Skull, J. Jeffery, L. Komar, C. Gillies, A. Jarvis, R. Jabbour, B. Wali, R. Teteruck, M. Seguin, D. White, M. Abraham, J. Tolkin, T. Rutledge, E. McLeod, E. King, M. Davies, S. Dempsey, M. A. Pinch, D. Thornley, F. Smaill

Résultat de recherche: Article › examen par les pairs

76 Citations (Scopus)

Résumé

Objective. To determine the viral etiology of community-acquired diarrhea in children admitted to hospitals and presenting in emergency departments, pediatric practices and child care centers from November 1, 1997, to June 30, 1998. Study design. Children with diarrhea were identified in a prospective multisite cohort study and analyzed according to age, gender and duration of hospitalization. Stools were tested for rotavirus by enzyme immunoassay and for all other enteric viruses by electron microscopy. Results. Of the 2524 children identified with diarrhea, stools of 1386 (55%) were tested by enzyme immunoassay for rotavirus, and of these 1365 (54%) were screened by electron microscopy for all identifiable enteric viruses. Rotavirus was found in 32% (n = 437), adenovirus in 4% (n = 55), torovirus in 3% (n = 44), Norwalk-like viruses in 2% (n = 25) and astrovirus (n = 14) and calicivirus (n = 7) in fewer than 1% of the specimens tested. The proportion of rotavirus was significantly higher in children 12 to 23 months of age (43% of tested stools, n = 159) and 24 to 35 months of age (38% of tested stools, n = 64) (P < 0.001) than in any other age group. Toroviruses were found to approximately the same extent in children ≥36 months of age (6% of tested stools, n = 19) as those <36 months of age. Rotavirus (36% of tested stools, n = 375, P < 0.0005) and torovirus (4% of tested stools, n = 43, P < 0.004) were most often found in hospitalized patients. In contrast Norwalk-like viruses (P < 0.001) and astroviruses (P < 0.01) were more commonly detected in specimens from patients who presented to physicians' offices and who were symptomatic for gastroenteritis in child care centers. Conclusion. This study demonstrates that although all known gastroenteritis viruses were diagnosed in symptomatic children, rotavirus was the etiologic agent in most cases of diarrhea managed in the community and in the hospital.

Langue d'origine	English
Pages (de-à)	843-848
Nombre de pages	6
Journal	Pediatric Infectious Disease Journal
Volume	19
Numéro de publication	9
DOI	https://doi.org/10.1097/00006454-200009000-00007
Statut de publication	Published - 2000
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1097/00006454-200009000-00007

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Waters, V., Ford-Jones, E. L., Petric, M., Fearon, M., Corey, P., Moineddein, R., Palmerino, L., Freeman, R., Urbshott, G., Wang, E., Petric, M., Ipp, M., Corey, P., Moineddin, R., Shane, L., Thompson, K., Wang, E. C. Y., McGeer, A., MacDonald, N., ... Smaill, F. (2000). Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998. Pediatric Infectious Disease Journal, 19(9), 843-848. https://doi.org/10.1097/00006454-200009000-00007

Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998. / Waters, V.; Ford-Jones, E. L.; Petric, M. et al.
Dans: Pediatric Infectious Disease Journal, Vol. 19, N° 9, 2000, p. 843-848.

Résultat de recherche: Article › examen par les pairs

Waters, V, Ford-Jones, EL, Petric, M, Fearon, M, Corey, P, Moineddein, R, Palmerino, L, Freeman, R, Urbshott, G, Wang, E, Petric, M, Ipp, M, Corey, P, Moineddin, R, Shane, L, Thompson, K, Wang, ECY, McGeer, A, MacDonald, N, Issenman, R, Fearon, M, Siu, K, Jazmaji, V, Stubberfield, J, Urquhart, J, Wark, K, Gilder, T, Pancer, A, Landry, L, Goldenberg, E, L'Estrange, L, Franceur, P, Marshall, A, Apted, S, Bates, M, Friendly, M, Beatty, H, Kawa, B, Rea, E, Yaffe, B, Shahin, R, Tooze, J, Misetic, M, Lewis, V, Mousseau, W, Kitai, I, Weinwurm, D, Kelly, M, Berall, G, Churilla, S, Moore, S, Levin, L, Court, M, Cote, L, Large, G, Cook, K, Azzopardi, P, Bajwa, G, Wyper, P, Belton, S, Vermaat, T, Lau, N, Thompson, J, Giles, L, Levy, M, Law, A, Beaulieu, R, Perkins, P, Mater, B, Pound, JL, Stavro-Sholdoff, T, Heurter, H, Siu, K, Nishikawa, J, Tellier, R, Davies, N, Pirie, J, Matlow, A, Read, SE, Skull, S, Jeffery, J, Komar, L, Gillies, C, Jarvis, A, Jabbour, R, Wali, B, Teteruck, R, Seguin, M, White, D, Abraham, M, Tolkin, J, Rutledge, T, McLeod, E, King, E, Davies, M, Dempsey, S, Pinch, MA, Thornley, D & Smaill, F 2000, 'Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998', Pediatric Infectious Disease Journal, vol. 19, n° 9, pp. 843-848. https://doi.org/10.1097/00006454-200009000-00007

Waters V, Ford-Jones EL, Petric M, Fearon M, Corey P, Moineddein R et al. Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998. Pediatric Infectious Disease Journal. 2000;19(9):843-848. doi: 10.1097/00006454-200009000-00007

@article{1dd0aae0c9454e2097dcc82f96c7dd87,

title = "Etiology of community-acquired pediatric viral diarrhea: A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998",

abstract = "Objective. To determine the viral etiology of community-acquired diarrhea in children admitted to hospitals and presenting in emergency departments, pediatric practices and child care centers from November 1, 1997, to June 30, 1998. Study design. Children with diarrhea were identified in a prospective multisite cohort study and analyzed according to age, gender and duration of hospitalization. Stools were tested for rotavirus by enzyme immunoassay and for all other enteric viruses by electron microscopy. Results. Of the 2524 children identified with diarrhea, stools of 1386 (55%) were tested by enzyme immunoassay for rotavirus, and of these 1365 (54%) were screened by electron microscopy for all identifiable enteric viruses. Rotavirus was found in 32% (n = 437), adenovirus in 4% (n = 55), torovirus in 3% (n = 44), Norwalk-like viruses in 2% (n = 25) and astrovirus (n = 14) and calicivirus (n = 7) in fewer than 1% of the specimens tested. The proportion of rotavirus was significantly higher in children 12 to 23 months of age (43% of tested stools, n = 159) and 24 to 35 months of age (38% of tested stools, n = 64) (P < 0.001) than in any other age group. Toroviruses were found to approximately the same extent in children ≥36 months of age (6% of tested stools, n = 19) as those <36 months of age. Rotavirus (36% of tested stools, n = 375, P < 0.0005) and torovirus (4% of tested stools, n = 43, P < 0.004) were most often found in hospitalized patients. In contrast Norwalk-like viruses (P < 0.001) and astroviruses (P < 0.01) were more commonly detected in specimens from patients who presented to physicians' offices and who were symptomatic for gastroenteritis in child care centers. Conclusion. This study demonstrates that although all known gastroenteritis viruses were diagnosed in symptomatic children, rotavirus was the etiologic agent in most cases of diarrhea managed in the community and in the hospital.",

author = "V. Waters and Ford-Jones, {E. L.} and M. Petric and M. Fearon and P. Corey and R. Moineddein and L. Palmerino and R. Freeman and G. Urbshott and E. Wang and M. Petric and M. Ipp and P. Corey and R. Moineddin and L. Shane and K. Thompson and Wang, {E. C.Y.} and A. McGeer and N. MacDonald and R. Issenman and M. Fearon and K. Siu and V. Jazmaji and J. Stubberfield and J. Urquhart and K. Wark and T. Gilder and A. Pancer and L. Landry and E. Goldenberg and L. L'Estrange and P. Franceur and A. Marshall and S. Apted and M. Bates and M. Friendly and H. Beatty and B. Kawa and E. Rea and B. Yaffe and R. Shahin and J. Tooze and M. Misetic and V. Lewis and W. Mousseau and I. Kitai and D. Weinwurm and M. Kelly and G. Berall and S. Churilla and S. Moore and L. Levin and M. Court and L. Cote and G. Large and K. Cook and P. Azzopardi and G. Bajwa and P. Wyper and S. Belton and T. Vermaat and N. Lau and J. Thompson and L. Giles and M. Levy and A. Law and R. Beaulieu and P. Perkins and B. Mater and Pound, {J. L.} and T. Stavro-Sholdoff and H. Heurter and K. Siu and J. Nishikawa and R. Tellier and N. Davies and J. Pirie and A. Matlow and Read, {S. E.} and S. Skull and J. Jeffery and L. Komar and C. Gillies and A. Jarvis and R. Jabbour and B. Wali and R. Teteruck and M. Seguin and D. White and M. Abraham and J. Tolkin and T. Rutledge and E. McLeod and E. King and M. Davies and S. Dempsey and Pinch, {M. A.} and D. Thornley and F. Smaill",

year = "2000",

doi = "10.1097/00006454-200009000-00007",

language = "English",

volume = "19",

pages = "843--848",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Etiology of community-acquired pediatric viral diarrhea

T2 - A prospective longitudinal study in hospitals, emergency departments, pediatric practices and child care centers during the winter rotavirus outbreak, 1997 to 1998

AU - Waters, V.

AU - Ford-Jones, E. L.

AU - Petric, M.

AU - Fearon, M.

AU - Corey, P.

AU - Moineddein, R.

AU - Palmerino, L.

AU - Freeman, R.

AU - Urbshott, G.

AU - Wang, E.

AU - Petric, M.

AU - Ipp, M.

AU - Corey, P.

AU - Moineddin, R.

AU - Shane, L.

AU - Thompson, K.

AU - Wang, E. C.Y.

AU - McGeer, A.

AU - MacDonald, N.

AU - Issenman, R.

AU - Fearon, M.

AU - Siu, K.

AU - Jazmaji, V.

AU - Stubberfield, J.

AU - Urquhart, J.

AU - Wark, K.

AU - Gilder, T.

AU - Pancer, A.

AU - Landry, L.

AU - Goldenberg, E.

AU - L'Estrange, L.

AU - Franceur, P.

AU - Marshall, A.

AU - Apted, S.

AU - Bates, M.

AU - Friendly, M.

AU - Beatty, H.

AU - Kawa, B.

AU - Rea, E.

AU - Yaffe, B.

AU - Shahin, R.

AU - Tooze, J.

AU - Misetic, M.

AU - Lewis, V.

AU - Mousseau, W.

AU - Kitai, I.

AU - Weinwurm, D.

AU - Kelly, M.

AU - Berall, G.

AU - Churilla, S.

AU - Moore, S.

AU - Levin, L.

AU - Court, M.

AU - Cote, L.

AU - Large, G.

AU - Cook, K.

AU - Azzopardi, P.

AU - Bajwa, G.

AU - Wyper, P.

AU - Belton, S.

AU - Vermaat, T.

AU - Lau, N.

AU - Thompson, J.

AU - Giles, L.

AU - Levy, M.

AU - Law, A.

AU - Beaulieu, R.

AU - Perkins, P.

AU - Mater, B.

AU - Pound, J. L.

AU - Stavro-Sholdoff, T.

AU - Heurter, H.

AU - Siu, K.

AU - Nishikawa, J.

AU - Tellier, R.

AU - Davies, N.

AU - Pirie, J.

AU - Matlow, A.

AU - Read, S. E.

AU - Skull, S.

AU - Jeffery, J.

AU - Komar, L.

AU - Gillies, C.

AU - Jarvis, A.

AU - Jabbour, R.

AU - Wali, B.

AU - Teteruck, R.

AU - Seguin, M.

AU - White, D.

AU - Abraham, M.

AU - Tolkin, J.

AU - Rutledge, T.

AU - McLeod, E.

AU - King, E.

AU - Davies, M.

AU - Dempsey, S.

AU - Pinch, M. A.

AU - Thornley, D.

AU - Smaill, F.

PY - 2000

Y1 - 2000

N2 - Objective. To determine the viral etiology of community-acquired diarrhea in children admitted to hospitals and presenting in emergency departments, pediatric practices and child care centers from November 1, 1997, to June 30, 1998. Study design. Children with diarrhea were identified in a prospective multisite cohort study and analyzed according to age, gender and duration of hospitalization. Stools were tested for rotavirus by enzyme immunoassay and for all other enteric viruses by electron microscopy. Results. Of the 2524 children identified with diarrhea, stools of 1386 (55%) were tested by enzyme immunoassay for rotavirus, and of these 1365 (54%) were screened by electron microscopy for all identifiable enteric viruses. Rotavirus was found in 32% (n = 437), adenovirus in 4% (n = 55), torovirus in 3% (n = 44), Norwalk-like viruses in 2% (n = 25) and astrovirus (n = 14) and calicivirus (n = 7) in fewer than 1% of the specimens tested. The proportion of rotavirus was significantly higher in children 12 to 23 months of age (43% of tested stools, n = 159) and 24 to 35 months of age (38% of tested stools, n = 64) (P < 0.001) than in any other age group. Toroviruses were found to approximately the same extent in children ≥36 months of age (6% of tested stools, n = 19) as those <36 months of age. Rotavirus (36% of tested stools, n = 375, P < 0.0005) and torovirus (4% of tested stools, n = 43, P < 0.004) were most often found in hospitalized patients. In contrast Norwalk-like viruses (P < 0.001) and astroviruses (P < 0.01) were more commonly detected in specimens from patients who presented to physicians' offices and who were symptomatic for gastroenteritis in child care centers. Conclusion. This study demonstrates that although all known gastroenteritis viruses were diagnosed in symptomatic children, rotavirus was the etiologic agent in most cases of diarrhea managed in the community and in the hospital.

AB - Objective. To determine the viral etiology of community-acquired diarrhea in children admitted to hospitals and presenting in emergency departments, pediatric practices and child care centers from November 1, 1997, to June 30, 1998. Study design. Children with diarrhea were identified in a prospective multisite cohort study and analyzed according to age, gender and duration of hospitalization. Stools were tested for rotavirus by enzyme immunoassay and for all other enteric viruses by electron microscopy. Results. Of the 2524 children identified with diarrhea, stools of 1386 (55%) were tested by enzyme immunoassay for rotavirus, and of these 1365 (54%) were screened by electron microscopy for all identifiable enteric viruses. Rotavirus was found in 32% (n = 437), adenovirus in 4% (n = 55), torovirus in 3% (n = 44), Norwalk-like viruses in 2% (n = 25) and astrovirus (n = 14) and calicivirus (n = 7) in fewer than 1% of the specimens tested. The proportion of rotavirus was significantly higher in children 12 to 23 months of age (43% of tested stools, n = 159) and 24 to 35 months of age (38% of tested stools, n = 64) (P < 0.001) than in any other age group. Toroviruses were found to approximately the same extent in children ≥36 months of age (6% of tested stools, n = 19) as those <36 months of age. Rotavirus (36% of tested stools, n = 375, P < 0.0005) and torovirus (4% of tested stools, n = 43, P < 0.004) were most often found in hospitalized patients. In contrast Norwalk-like viruses (P < 0.001) and astroviruses (P < 0.01) were more commonly detected in specimens from patients who presented to physicians' offices and who were symptomatic for gastroenteritis in child care centers. Conclusion. This study demonstrates that although all known gastroenteritis viruses were diagnosed in symptomatic children, rotavirus was the etiologic agent in most cases of diarrhea managed in the community and in the hospital.

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U2 - 10.1097/00006454-200009000-00007

DO - 10.1097/00006454-200009000-00007

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JO - Pediatric Infectious Disease Journal

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