Face and gaze perception in borderline personality disorder: An electrical neuroimaging study

Cristina Berchio; Camille Piguet; Kornelia Gentsch; Anne Lise Küng; Tonia A. Rihs; Roland Hasler; Jean Michel Aubry; Alexandre Dayer; Christoph M. Michel; Nader Perroud

doi:10.1016/j.pscychresns.2017.08.011

Face and gaze perception in borderline personality disorder: An electrical neuroimaging study

Cristina Berchio, Camille Piguet, Kornelia Gentsch, Anne Lise Küng, Tonia A. Rihs, Roland Hasler, Jean Michel Aubry, Alexandre Dayer, Christoph M. Michel, Nader Perroud

Résultat de recherche: Article › examen par les pairs

15 Citations (Scopus)

Résumé

Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces. High density EEG data were acquired in 19 females with BPD and 19 healthy women, and analyzed with a spatio-temporal microstates analysis approach. Independently of gaze direction, BPD patients showed altered N170 and P200 topographies for neutral faces. Source localization revealed that the anterior cingulate and other prefrontal regions were abnormally activated during the N170 component related to face encoding, while middle temporal deactivations were observed during the P200 component. Post-task affective ratings showed that BPD patients had difficulty to disambiguate neutral gaze. This study provides first evidence for an early neural bias toward neutral faces in BPD independent of gaze direction and also suggests the importance of considering basic aspects of social cognition in identifying biological risk factors of BPD.

Langue d'origine	English
Pages (de-à)	62-72
Nombre de pages	11
Journal	Psychiatry Research - Neuroimaging
Volume	269
DOI	https://doi.org/10.1016/j.pscychresns.2017.08.011
Statut de publication	Published - nov. 30 2017
Publié à l'externe	Oui

Note bibliographique

Funding Information:
The study was supported by the Swiss National Center of Competence in Research , “Synapsy: the Synaptic Basis of Mental Diseases” [grant number. 51NF40-158776 ], as well as a grant of the Swiss National Science Foundation to C.M. [grant number 320030_159705 ]. The Cartool software is freely available academic software that has been programmed by Denis Brunet ( http://www.unige.ch/medecine/neuf/en/research/christoph-1/cartool-software/ ). Special thanks go to Samika Kumar, and Alexandra Souchkova for their valuable contribution in editing the manuscript. The authors declare no conflicts of interest.

Publisher Copyright:
© 2017 The Authors

ASJC Scopus Subject Areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/j.pscychresns.2017.08.011

Autres fichiers et liens

Citer

@article{df66bf501e8a418590260a736c7bd61c,

title = "Face and gaze perception in borderline personality disorder: An electrical neuroimaging study",

abstract = "Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces. High density EEG data were acquired in 19 females with BPD and 19 healthy women, and analyzed with a spatio-temporal microstates analysis approach. Independently of gaze direction, BPD patients showed altered N170 and P200 topographies for neutral faces. Source localization revealed that the anterior cingulate and other prefrontal regions were abnormally activated during the N170 component related to face encoding, while middle temporal deactivations were observed during the P200 component. Post-task affective ratings showed that BPD patients had difficulty to disambiguate neutral gaze. This study provides first evidence for an early neural bias toward neutral faces in BPD independent of gaze direction and also suggests the importance of considering basic aspects of social cognition in identifying biological risk factors of BPD.",

author = "Cristina Berchio and Camille Piguet and Kornelia Gentsch and K{\"u}ng, {Anne Lise} and Rihs, {Tonia A.} and Roland Hasler and Aubry, {Jean Michel} and Alexandre Dayer and Michel, {Christoph M.} and Nader Perroud",

note = "Funding Information: The study was supported by the Swiss National Center of Competence in Research , “Synapsy: the Synaptic Basis of Mental Diseases” [grant number. 51NF40-158776 ], as well as a grant of the Swiss National Science Foundation to C.M. [grant number 320030_159705 ]. The Cartool software is freely available academic software that has been programmed by Denis Brunet ( http://www.unige.ch/medecine/neuf/en/research/christoph-1/cartool-software/ ). Special thanks go to Samika Kumar, and Alexandra Souchkova for their valuable contribution in editing the manuscript. The authors declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = nov,

day = "30",

doi = "10.1016/j.pscychresns.2017.08.011",

language = "English",

volume = "269",

pages = "62--72",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Face and gaze perception in borderline personality disorder

T2 - An electrical neuroimaging study

AU - Berchio, Cristina

AU - Piguet, Camille

AU - Gentsch, Kornelia

AU - Küng, Anne Lise

AU - Rihs, Tonia A.

AU - Hasler, Roland

AU - Aubry, Jean Michel

AU - Dayer, Alexandre

AU - Michel, Christoph M.

AU - Perroud, Nader

N1 - Funding Information: The study was supported by the Swiss National Center of Competence in Research , “Synapsy: the Synaptic Basis of Mental Diseases” [grant number. 51NF40-158776 ], as well as a grant of the Swiss National Science Foundation to C.M. [grant number 320030_159705 ]. The Cartool software is freely available academic software that has been programmed by Denis Brunet ( http://www.unige.ch/medecine/neuf/en/research/christoph-1/cartool-software/ ). Special thanks go to Samika Kumar, and Alexandra Souchkova for their valuable contribution in editing the manuscript. The authors declare no conflicts of interest. Publisher Copyright: © 2017 The Authors

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces. High density EEG data were acquired in 19 females with BPD and 19 healthy women, and analyzed with a spatio-temporal microstates analysis approach. Independently of gaze direction, BPD patients showed altered N170 and P200 topographies for neutral faces. Source localization revealed that the anterior cingulate and other prefrontal regions were abnormally activated during the N170 component related to face encoding, while middle temporal deactivations were observed during the P200 component. Post-task affective ratings showed that BPD patients had difficulty to disambiguate neutral gaze. This study provides first evidence for an early neural bias toward neutral faces in BPD independent of gaze direction and also suggests the importance of considering basic aspects of social cognition in identifying biological risk factors of BPD.

AB - Humans are sensitive to gaze direction from early life, and gaze has social and affective values. Borderline personality disorder (BPD) is a clinical condition characterized by emotional dysregulation and enhanced sensitivity to affective and social cues. In this study we wanted to investigate the temporal-spatial dynamics of spontaneous gaze processing in BPD. We used a 2-back-working-memory task, in which neutral faces with direct and averted gaze were presented. Gaze was used as an emotional modulator of event-related-potentials to faces. High density EEG data were acquired in 19 females with BPD and 19 healthy women, and analyzed with a spatio-temporal microstates analysis approach. Independently of gaze direction, BPD patients showed altered N170 and P200 topographies for neutral faces. Source localization revealed that the anterior cingulate and other prefrontal regions were abnormally activated during the N170 component related to face encoding, while middle temporal deactivations were observed during the P200 component. Post-task affective ratings showed that BPD patients had difficulty to disambiguate neutral gaze. This study provides first evidence for an early neural bias toward neutral faces in BPD independent of gaze direction and also suggests the importance of considering basic aspects of social cognition in identifying biological risk factors of BPD.

UR - http://www.scopus.com/inward/record.url?scp=85029697947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029697947&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2017.08.011

DO - 10.1016/j.pscychresns.2017.08.011

M3 - Article

C2 - 28941875

AN - SCOPUS:85029697947

SN - 0925-4927

VL - 269

SP - 62

EP - 72

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

ER -

Face and gaze perception in borderline personality disorder: An electrical neuroimaging study

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer