Frailty and Risk of Dementia in Mild Cognitive Impairment Subtypes

David D. Ward; Lindsay M.K. Wallace; Kenneth Rockwood

doi:10.1002/ana.26064

Frailty and Risk of Dementia in Mild Cognitive Impairment Subtypes

David D. Ward, Lindsay M.K. Wallace, Kenneth Rockwood

Résultat de recherche: Article › examen par les pairs

32 Citations (Scopus)

Résumé

Risk factors for developing dementia from mild cognitive impairment (MCI) probably differ between MCI subtypes. We investigated how frailty relates to dementia risk in amnestic MCI (a-MCI; n = 2,799) and non-amnestic MCI (na-MCI; n = 629) in the National Alzheimer's Coordinating Center database. Although higher frailty increased dementia risk for people with either a-MCI or na-MCI, the larger risk was in na-MCI (interaction hazard ratio = 1.35 [95% confidence interval = 1.15–1.59], p < 0.001). Even after the onset of clinically significant cognitive impairment, poor general health, quantified by a high degree of frailty, is a significant risk for dementia. ANN NEUROL 2021;89:1221–1225.

Langue d'origine	English
Pages (de-à)	1221-1225
Nombre de pages	5
Journal	Annals of Neurology
Volume	89
Numéro de publication	6
DOI	https://doi.org/10.1002/ana.26064
Statut de publication	Published - juin 2021

Note bibliographique

Funding Information:
This work was supported by a Canadian Institutes of Health Research Project Grant (PJT‐156114) and by the Canadian Consortium on Neurodegeneration in Aging. L.M.K.W. receives salary support from the Canadian Institutes of Health Research Banting Fellowship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research, and research support from the Canadian Institutes of Health Research, the Nova Scotia Health Research Foundation, the Canadian Frailty Network, the Capital Health Research Fund, and the Fountain Family Innovation Fund of QEII Health Sciences Centre Foundation. The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA‐funded ADRCs, the full list of which is presented in Supplementary Table S2 , along with funding information.

Funding Information:
This work was supported by a Canadian Institutes of Health Research Project Grant (PJT-156114) and by the Canadian Consortium on Neurodegeneration in Aging. L.M.K.W. receives salary support from the Canadian Institutes of Health Research Banting Fellowship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research, and research support from the Canadian Institutes of Health Research, the Nova Scotia Health Research Foundation, the Canadian Frailty Network, the Capital Health Research Fund, and the Fountain Family Innovation Fund of QEII Health Sciences Centre Foundation. The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA-funded ADRCs, the full list of which is presented in Supplementary Table S2, along with funding information.

Publisher Copyright:
© 2021 American Neurological Association.

ASJC Scopus Subject Areas

Neurology
Clinical Neurology

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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10.1002/ana.26064

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abstract = "Risk factors for developing dementia from mild cognitive impairment (MCI) probably differ between MCI subtypes. We investigated how frailty relates to dementia risk in amnestic MCI (a-MCI; n = 2,799) and non-amnestic MCI (na-MCI; n = 629) in the National Alzheimer's Coordinating Center database. Although higher frailty increased dementia risk for people with either a-MCI or na-MCI, the larger risk was in na-MCI (interaction hazard ratio = 1.35 [95% confidence interval = 1.15–1.59], p < 0.001). Even after the onset of clinically significant cognitive impairment, poor general health, quantified by a high degree of frailty, is a significant risk for dementia. ANN NEUROL 2021;89:1221–1225.",

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note = "Funding Information: This work was supported by a Canadian Institutes of Health Research Project Grant (PJT‐156114) and by the Canadian Consortium on Neurodegeneration in Aging. L.M.K.W. receives salary support from the Canadian Institutes of Health Research Banting Fellowship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research, and research support from the Canadian Institutes of Health Research, the Nova Scotia Health Research Foundation, the Canadian Frailty Network, the Capital Health Research Fund, and the Fountain Family Innovation Fund of QEII Health Sciences Centre Foundation. The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA‐funded ADRCs, the full list of which is presented in Supplementary Table S2 , along with funding information. Funding Information: This work was supported by a Canadian Institutes of Health Research Project Grant (PJT-156114) and by the Canadian Consortium on Neurodegeneration in Aging. L.M.K.W. receives salary support from the Canadian Institutes of Health Research Banting Fellowship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research, and research support from the Canadian Institutes of Health Research, the Nova Scotia Health Research Foundation, the Canadian Frailty Network, the Capital Health Research Fund, and the Fountain Family Innovation Fund of QEII Health Sciences Centre Foundation. The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA-funded ADRCs, the full list of which is presented in Supplementary Table S2, along with funding information. Publisher Copyright: {\textcopyright} 2021 American Neurological Association.",

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Frailty and Risk of Dementia in Mild Cognitive Impairment Subtypes

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

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