Résumé
Introduction: Frailty is recognized as a clinical condition associated with increased vulnerability for developing negative health outcomes but has been little studied in patients with Parkinson's disease (PD). Here, we investigated the risk of frailty in de novo PD patients and its association with subsequent development of dementia. Methods: We conducted a three-year longitudinal population-based study of 192 drug-naive newly diagnosed PD patients and 172 controls (No-PD) matched for age, sex, and education. Frailty was measured using the frailty index (FI). Logistic regression models, adjusting for potential confounders, were conducted to assess the association between frailty at the time of PD diagnosis and the subsequent odds for developing PD dementia during follow-up. Results: The mean baseline FI score was higher in the PD (0.21 ± 0.10) than in the No-PD group (0.11 ± 0.07, p < 0.001). One-third of PD patients had high-FI (>0,25), compared to 5% in the no-PD group. Participants with PD had an increased risk to present frailty with an odds ratio (OR) of 6.68 (SE 2.70 IC 95% [3.15; 15.62], p-value <0.001) compared to the No-PD group. PD Participants with greater FI measured at baseline had increased odds of having dementia within three years of follow-up, after adjustment for age and sex (OR 2.91 SE 1.00 IC 95% [1.54; 5.99] p-value = 0.002). Conclusion: Frailty is common in people with newly diagnosed PD and associated with increased odds for subsequent development of dementia in a three-year follow-up. This study emphasizes the prognostic importance of frailty in PD from the earliest clinical stages.
Langue d'origine | English |
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Pages (de-à) | 51-57 |
Nombre de pages | 7 |
Journal | Parkinsonism and Related Disorders |
Volume | 99 |
DOI | |
Statut de publication | Published - juin 2022 |
Note bibliographique
Funding Information:This paper represents independent research supported by the Norwegian government, through hospital owner Helse Vest ( Western Norway Regional Health Authority ). Also, funded by the National Institute for Health Research ( NIHR ) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London . The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. LW is supported by a Canadian Institutes of Health Research Banting Postdoctoral Fellowship award.
Publisher Copyright:
© 2022 The Authors
ASJC Scopus Subject Areas
- Neurology
- Geriatrics and Gerontology
- Clinical Neurology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't