Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer

Erin A. Marshall; Kevin W. Ng; Christine Anderson; Roland Hubaux; Kelsie L. Thu; Wan L. Lam; Victor D. Martinez

doi:10.1016/j.gdata.2015.08.011

Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer

Erin A. Marshall, Kevin W. Ng, Christine Anderson, Roland Hubaux, Kelsie L. Thu, Wan L. Lam, Victor D. Martinez

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9 Citations (Scopus)

Résumé

Lung cancer is the leading cause of cancer death worldwide, and has a five-year survival rate of 18% [1]. MARK2 is a serine/threonine-protein kinase, and is a key component in the phosphorylation of microtubule-associated proteins [2,3]. A recent study published by Hubaux et al. found that microtubule affinity-regulating kinase 2 (MARK2) showed highly frequent DNA and RNA level disruption in lung cancer cell lines and independent non-small cell lung cancer (NSCLC) cohorts [4]. These alterations result in the acquisition of oncogenic properties in cell lines, such as increased viability and anchorage-independent growth. Furthermore, a microarray-based transcriptome analysis of three short hairpin RNA (shRNA)-mediated MARK2 knockdown lung adenocarcinoma cell lines (GEO#: GSE57966) revealed an association between MARK2 gene expression and cell cycle activation and DNA damage response. Here, we present a detailed description of transcriptome analysis to support the described role of MARK2 in promoting a malignant phenotype.

Langue d'origine	English
Pages (de-à)	145-148
Nombre de pages	4
Journal	Genomics Data
Volume	6
DOI	https://doi.org/10.1016/j.gdata.2015.08.011
Statut de publication	Published - déc. 15 2015
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This work was supported by grants from the Canadian Institutes for Health Research (CIHR) ( MOP-97839 and MOP-123273 ). E.A.M. and C.A. are supported by a BC Cancer Studentship , C.A. by CBCF Studentship , K.L.T. by Vanier Canada Scholarship .

Publisher Copyright:
© 2015 The Authors.

ASJC Scopus Subject Areas

Biotechnology
Biochemistry
Molecular Medicine
Genetics

PubMed: MeSH publication types

Journal Article

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Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/j.gdata.2015.08.011

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abstract = "Lung cancer is the leading cause of cancer death worldwide, and has a five-year survival rate of 18% [1]. MARK2 is a serine/threonine-protein kinase, and is a key component in the phosphorylation of microtubule-associated proteins [2,3]. A recent study published by Hubaux et al. found that microtubule affinity-regulating kinase 2 (MARK2) showed highly frequent DNA and RNA level disruption in lung cancer cell lines and independent non-small cell lung cancer (NSCLC) cohorts [4]. These alterations result in the acquisition of oncogenic properties in cell lines, such as increased viability and anchorage-independent growth. Furthermore, a microarray-based transcriptome analysis of three short hairpin RNA (shRNA)-mediated MARK2 knockdown lung adenocarcinoma cell lines (GEO#: GSE57966) revealed an association between MARK2 gene expression and cell cycle activation and DNA damage response. Here, we present a detailed description of transcriptome analysis to support the described role of MARK2 in promoting a malignant phenotype.",

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doi = "10.1016/j.gdata.2015.08.011",

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AU - Marshall, Erin A.

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AU - Hubaux, Roland

AU - Thu, Kelsie L.

AU - Lam, Wan L.

AU - Martinez, Victor D.

N1 - Funding Information: This work was supported by grants from the Canadian Institutes for Health Research (CIHR) ( MOP-97839 and MOP-123273 ). E.A.M. and C.A. are supported by a BC Cancer Studentship , C.A. by CBCF Studentship , K.L.T. by Vanier Canada Scholarship . Publisher Copyright: © 2015 The Authors.

PY - 2015/12/15

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N2 - Lung cancer is the leading cause of cancer death worldwide, and has a five-year survival rate of 18% [1]. MARK2 is a serine/threonine-protein kinase, and is a key component in the phosphorylation of microtubule-associated proteins [2,3]. A recent study published by Hubaux et al. found that microtubule affinity-regulating kinase 2 (MARK2) showed highly frequent DNA and RNA level disruption in lung cancer cell lines and independent non-small cell lung cancer (NSCLC) cohorts [4]. These alterations result in the acquisition of oncogenic properties in cell lines, such as increased viability and anchorage-independent growth. Furthermore, a microarray-based transcriptome analysis of three short hairpin RNA (shRNA)-mediated MARK2 knockdown lung adenocarcinoma cell lines (GEO#: GSE57966) revealed an association between MARK2 gene expression and cell cycle activation and DNA damage response. Here, we present a detailed description of transcriptome analysis to support the described role of MARK2 in promoting a malignant phenotype.

AB - Lung cancer is the leading cause of cancer death worldwide, and has a five-year survival rate of 18% [1]. MARK2 is a serine/threonine-protein kinase, and is a key component in the phosphorylation of microtubule-associated proteins [2,3]. A recent study published by Hubaux et al. found that microtubule affinity-regulating kinase 2 (MARK2) showed highly frequent DNA and RNA level disruption in lung cancer cell lines and independent non-small cell lung cancer (NSCLC) cohorts [4]. These alterations result in the acquisition of oncogenic properties in cell lines, such as increased viability and anchorage-independent growth. Furthermore, a microarray-based transcriptome analysis of three short hairpin RNA (shRNA)-mediated MARK2 knockdown lung adenocarcinoma cell lines (GEO#: GSE57966) revealed an association between MARK2 gene expression and cell cycle activation and DNA damage response. Here, we present a detailed description of transcriptome analysis to support the described role of MARK2 in promoting a malignant phenotype.

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Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

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