Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency

Leah E. Cahill, Ahmed El-Sohemy

Résultat de recherche: Articleexamen par les pairs

47 Citations (Scopus)

Résumé

Background: Haptoglobin (which is encoded by the Hp gene) is a hemoglobin-binding protein that has antioxidant properties and a common polymorphism that consists of 2 structurally different alleles: Hp1 and Hp2. The capacity of Hp2 to inhibit oxidation and vitamin C depletion is less than that of Hp1, but the influence on vitamin C requirements remains unknown. Objective: This study aimed to determine whether the Hp polymorphism modifies the association between dietary vitamin C and serum ascorbic acid deficiency (<11 lmol/L). Design: Nonsmoking men and women (n = 1046) between 20 and 29 y of age participated in the Toronto Nutrigenomics and Health Study. Blood samples were collected after the subjects had fasted overnight to determine serum ascorbic acid concentrations by HPLC and for genotyping. A 196-item food-frequency questionnaire was used to estimate vitamin C intake. Results: A gene-diet interaction on serum ascorbic acid was observed (P = 0.02). The overall odds ratio (95% CI) for serum ascorbic acid deficiency was 2.84 (1.73, 4.65) for subjects who did not meet the Recommended Dietary Allowance for vitamin C compared with those who did. The corresponding odds ratios were 4.77 (2.36, 9.65) for the Hp2-2 genotype and 1.69 (0.80, 3.63) for carriers of the Hp1 allele. Conclusions: Individuals with the Hp2-2 genotype had an increased risk of deficiency if they did not meet the Recommended Dietary Allowance for vitamin C, whereas carriers of the Hp1 allele did not. The findings suggest that the greater antioxidant capacity of Hp1 might spare serum ascorbic acid.

Langue d'origineEnglish
Pages (de-à)1494-1500
Nombre de pages7
JournalAmerican Journal of Clinical Nutrition
Volume92
Numéro de publication6
DOI
Statut de publicationPublished - déc. 1 2010
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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