HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors

Paul J. McLaren; T. Blake Ball; Charles Wachihi; Walter Jaoko; David J. Kelvin; Ali Danesh; Joshua Kimani; Francis A. Plummer; Keith R. Fowke

doi:10.1086/655968

HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4⁺ T cell compartment and reduced expression of HIV-dependent host factors

Paul J. McLaren, T. Blake Ball, Charles Wachihi, Walter Jaoko, David J. Kelvin, Ali Danesh, Joshua Kimani, Francis A. Plummer, Keith R. Fowke

Résultat de recherche: Article › examen par les pairs

101 Citations (Scopus)

Résumé

Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed that CD4⁺ T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level of gene expression that can be seen in differentially expressed genes and systems crucial for HIV replication, such as the T cell receptor pathway and previously identified HIV dependency factors. This apparent lowered activation results in a phenomenon we term "immune quiescence," which may contribute to host resistance to HIV.

Langue d'origine	English
Pages (de-à)	S339-S344
Journal	Journal of Infectious Diseases
Volume	202
Numéro de publication	SUPP.3
DOI	https://doi.org/10.1086/655968
Statut de publication	Published - nov. 1 2010
Publié à l'externe	Oui

Note bibliographique

Funding Information:
Supplement sponsorship: This article is part of a supplement entitled “Natural Immunity to HIV-1 Infection,” sponsored by the Bill and Melinda Gates Foundation and the University of Manitoba.

Funding Information:
Financial support: Canadian Institutes for Health Research (CIHR) (grants HOP-75348 and MDP-86721; New Investigator Salary Award to K.R.F.); CIHR/ International Center for Infectious Diseases National Training Program in Infectious Diseases, hosted at the University of Manitoba (P.J.M.); Manitoba Research Chair (K.R.F.).

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1086/655968

Autres fichiers et liens

Citer

McLaren, P. J., Blake Ball, T., Wachihi, C., Jaoko, W., Kelvin, D. J., Danesh, A., Kimani, J., Plummer, F. A., & Fowke, K. R. (2010). HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4⁺ T cell compartment and reduced expression of HIV-dependent host factors. Journal of Infectious Diseases, 202(SUPP.3), S339-S344. https://doi.org/10.1086/655968

McLaren, PJ, Blake Ball, T, Wachihi, C, Jaoko, W, Kelvin, DJ, Danesh, A, Kimani, J, Plummer, FA & Fowke, KR 2010, 'HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4⁺ T cell compartment and reduced expression of HIV-dependent host factors', Journal of Infectious Diseases, vol. 202, n° SUPP.3, pp. S339-S344. https://doi.org/10.1086/655968

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abstract = "Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed that CD4+ T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level of gene expression that can be seen in differentially expressed genes and systems crucial for HIV replication, such as the T cell receptor pathway and previously identified HIV dependency factors. This apparent lowered activation results in a phenomenon we term {"}immune quiescence,{"} which may contribute to host resistance to HIV.",

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