HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy

Anne Marie Madore; Vanessa T. Vaillancourt; Yuka Asai; Reza Alizadehfar; Moshe Ben-Shoshan; Deborah L. Michel; Anita L. Kozyrskyj; Allan Becker; Moira Chan-Yeung; Ann E. Clarke; Peter Hull; Denise Daley; Andrew J. Sandford; Catherine Laprise

doi:10.1038/ejhg.2013.13

HLA-DQB102 and DQB106:03P are associated with peanut allergy

Anne Marie Madore, Vanessa T. Vaillancourt, Yuka Asai, Reza Alizadehfar, Moshe Ben-Shoshan, Deborah L. Michel, Anita L. Kozyrskyj, Allan Becker, Moira Chan-Yeung, Ann E. Clarke, Peter Hull, Denise Daley, Andrew J. Sandford, Catherine Laprise

Résultat de recherche: Article › examen par les pairs

42 Citations (Scopus)

Résumé

Peanut allergy (PA) is a common and serious food allergy and its prevalence has increased in the past decade. Although there is strong evidence of inheritance, the genetic causes of this disease are not well understood. Previously, a large-scale genome-wide association study described an association between human leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate the association between HLA-DQB1 and PA. Genotypic and allelic profiles were established for 311 Caucasian members of a well-described Canadian group of children with PA and 226 Caucasian controls. Firth's logistic regression analyses showed associations between HLA-DQB1 alleles and PA for DQB1*02 (P=1.1 × 10 -8, odds ratio (OR)=0.09 (CI=0.03-0.23)) and DQB1*06:03P alleles (P=2.1 × 10 -2, OR=2.82 (CI=1.48-5.45)). This study of HLA in PA demonstrates specific association between two allelic groups of the HLA-DQB1 gene (DQB1*02 and DQB1*06:03P) and PA, highlighting its possible role in the development of this disease.

Langue d'origine	English
Pages (de-à)	1181-1184
Nombre de pages	4
Journal	European Journal of Human Genetics
Volume	21
Numéro de publication	10
DOI	https://doi.org/10.1038/ejhg.2013.13
Statut de publication	Published - oct. 2013
Publié à l'externe	Oui

Note bibliographique

Funding Information:
We thank all the individuals involved in this study for their participation and the funding organizations for their support. This study was supported by the AllerGen NCE (the Allergy, Genes and Environment Network of Centers of Excellence). VT Vaillancourt is an AllerGen NCE trainee and is supported by the Corporation de recherche et d’action sur les maladies héréditaires (CORAMH) and the Campagne de développement de l’Université du Québec à Chicoutimi. Y Asai is supported by a Canadian Institutes for Health Research (CIHR) Research fellowship, an AllerGen CAIDATI training award and the Canadian Dermatology Foundation (CDF). M Ben-Shoshan is an Emerging Clinician-Scientist of the AllerGen NCE. A Kozyrskyj is the WCHRI Research Chair in Maternal-Child Health and the Environment. D Daley has received grant support from CIHR and is a Michael Smith Foundation for Health Research Career Scholar and she holds a Tier II Canadian Research Chair (Genetics of Common Complex Diseases). A Clarke is a National Research Scholar of the Fonds de recherche du Québec–santé (FRQS). P Hull is supported by the CDF and the University of Saskatchewan’s Department of Medicine Research Fund. C Laprise holds the Canada Research Chair on Genetic Determinants in Asthma and is the director of the Inflammation and Remodeling Strategic Group of the Respiratory Health Network of the FRQS. A Kozyrskyj, A Becker, D Daley, A Sandford and C Laprise are AllerGen NCE members. The Canadian studies (SAGE and CAPPS studies) were supported by the AllerGen NCE. The McGill PA case group is supported by the Foundations of the McGill University Health Center and the Montreal Children’s Hospital as well as by grants from the Canadian Allergy, Asthma and Immunology Foundation and the AllerGen NCE.

ASJC Scopus Subject Areas

Genetics
Genetics(clinical)

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1038/ejhg.2013.13

Autres fichiers et liens

Citer

Madore, A. M., Vaillancourt, V. T., Asai, Y., Alizadehfar, R., Ben-Shoshan, M., Michel, D. L., Kozyrskyj, A. L., Becker, A., Chan-Yeung, M., Clarke, A. E., Hull, P., Daley, D., Sandford, A. J., & Laprise, C. (2013). HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy. European Journal of Human Genetics, 21(10), 1181-1184. https://doi.org/10.1038/ejhg.2013.13

@article{fa9b379d16b048caaa0e82b82d2fb04e,

title = "HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy",

abstract = "Peanut allergy (PA) is a common and serious food allergy and its prevalence has increased in the past decade. Although there is strong evidence of inheritance, the genetic causes of this disease are not well understood. Previously, a large-scale genome-wide association study described an association between human leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate the association between HLA-DQB1 and PA. Genotypic and allelic profiles were established for 311 Caucasian members of a well-described Canadian group of children with PA and 226 Caucasian controls. Firth's logistic regression analyses showed associations between HLA-DQB1 alleles and PA for DQB1*02 (P=1.1 × 10 -8, odds ratio (OR)=0.09 (CI=0.03-0.23)) and DQB1*06:03P alleles (P=2.1 × 10 -2, OR=2.82 (CI=1.48-5.45)). This study of HLA in PA demonstrates specific association between two allelic groups of the HLA-DQB1 gene (DQB1*02 and DQB1*06:03P) and PA, highlighting its possible role in the development of this disease.",

author = "Madore, {Anne Marie} and Vaillancourt, {Vanessa T.} and Yuka Asai and Reza Alizadehfar and Moshe Ben-Shoshan and Michel, {Deborah L.} and Kozyrskyj, {Anita L.} and Allan Becker and Moira Chan-Yeung and Clarke, {Ann E.} and Peter Hull and Denise Daley and Sandford, {Andrew J.} and Catherine Laprise",

note = "Funding Information: We thank all the individuals involved in this study for their participation and the funding organizations for their support. This study was supported by the AllerGen NCE (the Allergy, Genes and Environment Network of Centers of Excellence). VT Vaillancourt is an AllerGen NCE trainee and is supported by the Corporation de recherche et d{\textquoteright}action sur les maladies h{\'e}r{\'e}ditaires (CORAMH) and the Campagne de d{\'e}veloppement de l{\textquoteright}Universit{\'e} du Qu{\'e}bec {\`a} Chicoutimi. Y Asai is supported by a Canadian Institutes for Health Research (CIHR) Research fellowship, an AllerGen CAIDATI training award and the Canadian Dermatology Foundation (CDF). M Ben-Shoshan is an Emerging Clinician-Scientist of the AllerGen NCE. A Kozyrskyj is the WCHRI Research Chair in Maternal-Child Health and the Environment. D Daley has received grant support from CIHR and is a Michael Smith Foundation for Health Research Career Scholar and she holds a Tier II Canadian Research Chair (Genetics of Common Complex Diseases). A Clarke is a National Research Scholar of the Fonds de recherche du Qu{\'e}bec–sant{\'e} (FRQS). P Hull is supported by the CDF and the University of Saskatchewan{\textquoteright}s Department of Medicine Research Fund. C Laprise holds the Canada Research Chair on Genetic Determinants in Asthma and is the director of the Inflammation and Remodeling Strategic Group of the Respiratory Health Network of the FRQS. A Kozyrskyj, A Becker, D Daley, A Sandford and C Laprise are AllerGen NCE members. The Canadian studies (SAGE and CAPPS studies) were supported by the AllerGen NCE. The McGill PA case group is supported by the Foundations of the McGill University Health Center and the Montreal Children{\textquoteright}s Hospital as well as by grants from the Canadian Allergy, Asthma and Immunology Foundation and the AllerGen NCE.",

year = "2013",

month = oct,

doi = "10.1038/ejhg.2013.13",

language = "English",

volume = "21",

pages = "1181--1184",

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T1 - HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy

AU - Madore, Anne Marie

AU - Vaillancourt, Vanessa T.

AU - Asai, Yuka

AU - Alizadehfar, Reza

AU - Ben-Shoshan, Moshe

AU - Michel, Deborah L.

AU - Kozyrskyj, Anita L.

AU - Becker, Allan

AU - Chan-Yeung, Moira

AU - Clarke, Ann E.

AU - Hull, Peter

AU - Daley, Denise

AU - Sandford, Andrew J.

AU - Laprise, Catherine

N1 - Funding Information: We thank all the individuals involved in this study for their participation and the funding organizations for their support. This study was supported by the AllerGen NCE (the Allergy, Genes and Environment Network of Centers of Excellence). VT Vaillancourt is an AllerGen NCE trainee and is supported by the Corporation de recherche et d’action sur les maladies héréditaires (CORAMH) and the Campagne de développement de l’Université du Québec à Chicoutimi. Y Asai is supported by a Canadian Institutes for Health Research (CIHR) Research fellowship, an AllerGen CAIDATI training award and the Canadian Dermatology Foundation (CDF). M Ben-Shoshan is an Emerging Clinician-Scientist of the AllerGen NCE. A Kozyrskyj is the WCHRI Research Chair in Maternal-Child Health and the Environment. D Daley has received grant support from CIHR and is a Michael Smith Foundation for Health Research Career Scholar and she holds a Tier II Canadian Research Chair (Genetics of Common Complex Diseases). A Clarke is a National Research Scholar of the Fonds de recherche du Québec–santé (FRQS). P Hull is supported by the CDF and the University of Saskatchewan’s Department of Medicine Research Fund. C Laprise holds the Canada Research Chair on Genetic Determinants in Asthma and is the director of the Inflammation and Remodeling Strategic Group of the Respiratory Health Network of the FRQS. A Kozyrskyj, A Becker, D Daley, A Sandford and C Laprise are AllerGen NCE members. The Canadian studies (SAGE and CAPPS studies) were supported by the AllerGen NCE. The McGill PA case group is supported by the Foundations of the McGill University Health Center and the Montreal Children’s Hospital as well as by grants from the Canadian Allergy, Asthma and Immunology Foundation and the AllerGen NCE.

PY - 2013/10

Y1 - 2013/10

N2 - Peanut allergy (PA) is a common and serious food allergy and its prevalence has increased in the past decade. Although there is strong evidence of inheritance, the genetic causes of this disease are not well understood. Previously, a large-scale genome-wide association study described an association between human leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate the association between HLA-DQB1 and PA. Genotypic and allelic profiles were established for 311 Caucasian members of a well-described Canadian group of children with PA and 226 Caucasian controls. Firth's logistic regression analyses showed associations between HLA-DQB1 alleles and PA for DQB1*02 (P=1.1 × 10 -8, odds ratio (OR)=0.09 (CI=0.03-0.23)) and DQB1*06:03P alleles (P=2.1 × 10 -2, OR=2.82 (CI=1.48-5.45)). This study of HLA in PA demonstrates specific association between two allelic groups of the HLA-DQB1 gene (DQB1*02 and DQB1*06:03P) and PA, highlighting its possible role in the development of this disease.

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