In-vitro activity of streptogramin RP 59500 against staphylococci, including bactericidal kinetic studies

D. J. Hoban, B. Weshnoweski, L. Palatnick, C. G. Zhaoel, R. J. Davidson

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33 Citations (Scopus)

Résumé

The in-vitro activity of RP 59500 and comparative agents was determined against 270 clinical isolates of the genus Staphylococcus. MICs were performed by micro-dilution dilution. MIC90 and MBG90 (mg/L) of RP 59500 were as follows: oxacillin-sensitive Staphylococcus aureus (0.5/0.5), oxacillin-resistant S. aureus (0.5/0.5), oxacillin-sensitive Staphylococcus epidermidis (0.5/0.5), oxacillin-resistant S. epidermidis (0.25/0.25), oxacillin-resistant Staphylococcus hominis (1.0/1.0), oxacillin-resistant Staphylococcus haemolyticus (1.0/1.0), oxacillin-sensitive Staphylococcus saprophyticus (1.0/1.0). Killing kinetic methods were used to assess the bactericidal activity of inhibitory (1 –, 2 – MIC) concentrations of RP 59500 in comparison with that of vancomycin (1 – 2 – MIC) and oxacillin (1 –, 2 – MIC) against 20 strains of oxacillin-sensitive and -resistant S. aureus and S. epidermidis. RP 59500 was as active as vancomycin, displaying rapid bactericidal activity against the majority of strains tested and reducing initial inoculum counts by >99.9% in 2-12 h. Regrowth was seen with some S. epidermidis strains after 12-24 h.

Langue d'origineEnglish
Pages (de-à)59-65
Nombre de pages7
JournalJournal of Antimicrobial Chemotherapy
Volume30
DOI
Statut de publicationPublished - 1992
Publié à l'externeOui

Note bibliographique

Funding Information:
This study was supported by a grant from Rhone-Poulenc Rorcr, Princeton, New Jersey. G. G. Zhancl was sponsored by a Postdoctoral Fellowship from the Medical Research Council of Canada and Pharmaceutical Manufacturers Association of Canada—Health Research Foundation. The expert secretarial assistance of Mary Wegrzyn is appreciated.

ASJC Scopus Subject Areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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