In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth

J. A. Karlowsky; G. G. Zhanel; R. J. Davidson; S. R. Zieroth; D. J. Hoban

doi:10.1128/AAC.37.5.1154

In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth

J. A. Karlowsky, G. G. Zhanel, R. J. Davidson, S. R. Zieroth, D. J. Hoban

Résultat de recherche: Article › examen par les pairs

23 Citations (Scopus)

Résumé

Multiple exposures with cefotaxime in either Mueller-Hinton broth or cerebrospinal fluid had no effect on killing or the duration of postantibiotic effect (PAE) in Escherichia coli strains tested. However, upon multiple exposures in Mueller-Hinton broth, ciprofloxacin and gentamicin PAEs significantly decreased with a concomitant reduction in bacterial killing. A reduction in bacterial killing following multiple ciprofloxacin and gentamicin exposures was also seen with cerebrospinal fluid; however, the PAE was maintained.

Langue d'origine	English
Pages (de-à)	1154-1157
Nombre de pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	37
Numéro de publication	5
DOI	https://doi.org/10.1128/AAC.37.5.1154
Statut de publication	Published - 1993
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1128/AAC.37.5.1154

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Citer

Karlowsky, J. A., Zhanel, G. G., Davidson, R. J., Zieroth, S. R., & Hoban, D. J. (1993). In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth. Antimicrobial Agents and Chemotherapy, 37(5), 1154-1157. https://doi.org/10.1128/AAC.37.5.1154

In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth. / Karlowsky, J. A.; Zhanel, G. G.; Davidson, R. J. et al.
Dans: Antimicrobial Agents and Chemotherapy, Vol. 37, N° 5, 1993, p. 1154-1157.

Résultat de recherche: Article › examen par les pairs

Karlowsky, JA, Zhanel, GG, Davidson, RJ, Zieroth, SR & Hoban, DJ 1993, 'In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth', Antimicrobial Agents and Chemotherapy, vol. 37, n° 5, pp. 1154-1157. https://doi.org/10.1128/AAC.37.5.1154

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