Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs

H. Zhu, D. Wang, D. J. Kelvin, L. Li, Z. Zheng, S. W. Yoon, S. S. Wong, A. Farooqui, J. Wang, D. Banner, R. Chen, R. Zheng, J. Zhou, Y. Zhang, W. Hong, W. Dong, Q. Cai, M. H.A. Roehrl, S. S.H. Huang, A. A. KelvinT. Yao, B. Zhou, X. Chen, G. M. Leung, L. L.M. Poon, R. G. Webster, R. J. Webby, J. S.M. Peiris, Y. Guan, Y. Shu

Résultat de recherche: Articleexamen par les pairs

264 Citations (Scopus)

Résumé

The emergence of the H7N9 influenza virus in humans in Eastern China has raised concerns that a new influenza pandemic could occur. Here, we used a ferret model to evaluate the infectivity and transmissibility of A/Shanghai/2/2013 (SH2), a human H7N9 virus isolate. This virus replicated in the upper and lower respiratory tracts of the ferrets and was shed at high titers for 6 to 7 days, with ferrets showing relatively mild clinical signs. SH2 was efficiently transmitted between ferrets via direct contact, but less efficiently by airborne exposure. Pigs were productively infected by SH2 and shed virus for 6 days but were unable to transmit the virus to naïve pigs or ferrets. Under appropriate conditions, human-to-human transmission of the H7N9 virus may be possible.

Langue d'origineEnglish
Pages (de-à)183-186
Nombre de pages4
JournalScience
Volume341
Numéro de publication6142
DOI
Statut de publicationPublished - 2013
Publié à l'externeOui

ASJC Scopus Subject Areas

  • General

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