Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China

Wen Yang; Jin Liu; Jing Li; Jinnan Liu; Hongyan Liu; Yue Wang; Junhong Leng; Shuo Wang; Huaxi Chen; Juliana C.N. Chan; Zhijie Yu; Gang Hu; Xilin Yang

doi:10.1016/j.diabres.2019.06.014

Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China

Wen Yang, Jin Liu, Jing Li, Jinnan Liu, Hongyan Liu, Yue Wang, Junhong Leng, Shuo Wang, Huaxi Chen, Juliana C.N. Chan, Zhijie Yu, Gang Hu, Xilin Yang

Medicine

Résultat de recherche: Article › examen par les pairs

21 Citations (Scopus)

Résumé

Aims: Obesity increases risk of gestational diabetes mellitus (GDM) and GDM increases risk of macrosomia but their inter-relations for increased risk of macrosomia remain uncertain. We aimed to examine associations between prepregnancy overweight and macrosomia, and synergistic effects between prepregnancy overweight and GDM on macrosomia. Methods: From 2010 to 2012, 19,622 women in urban Tianjin, China, underwent a 50-g 1-h glucose challenge test (GCT) at 24–28 gestational weeks and followed by a 75-g 2-h oral glucose tolerance test (OGTT) if the GCT value was ≥ 7.8 mmol/L. GDM was defined according to International Association of Diabetes and Pregnancy Study Group's criteria. Overweight was defined as body mass index ≥ 24.0 kg/m². Logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between prepregnancy overweight and GDM was used to test synergistic effects. Results: In the cohort, 1791 (9.1%) and 1726 (8.8%) of the women delivered a macrosomic infant or a large-for-gestational-age (LGA) infant, respectively. Prepregnancy overweight was associated with increased risk of macrosomia and LGA with adjusted ORs being 2.29 (95%CI: 2.07–2.54) and 2.27 (2.05–2.52), respectively. Copresence of prepregnancy overweight and GDM greatly enhanced the adjusted ORs of overweight alone (ORs for macrosomia and LGA: 2.17, 1.94–2.42 & 2.21,1.98–2.47) and GDM alone (ORs for macrosomia and LGA: 2.01,1.48–2.72 & 2.14, 1.60–2.87) for macrosomia and LGA to 5.29 (4.07–6.87) for macrosomia and 4.72 (3.66–6.10) for LGA, with significant additive interactions. Conclusions: Prepregnancy overweight increased the risks of macrosomia and LGA independently and synergistically with GDM.

Langue d'origine	English
Pages (de-à)	82-89
Nombre de pages	8
Journal	Diabetes Research and Clinical Practice
Volume	154
DOI	https://doi.org/10.1016/j.diabres.2019.06.014
Statut de publication	Published - août 2019

Note bibliographique

Funding Information:
The authors would like to express our special thanks to obstetricians and other health professionals in the 64 primary care hospitals and 6 district women and children's health care institutes who were involved in the setting up of the cohort. X.Y. conceived and designed the study. W.Y. analyzed the data and wrote the first draft, J.L. H.L. Y.W. J.L. and S.W. provided the study material and patients, collected and assembly the data; All other authors gave critical comments on the manuscript; X.Y. (the corresponding authors) and W.Y. (the first author) take full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript. All authors have read and approved the submission of the manuscript; the manuscript has not been published and is not being considered for publication elsewhere, in whole or in part, in any language. This study was supported by the National Key Research and Development Program of China (Grant number: 2018YFC1313903) and National Natural Science Foundation of China (Grant number: 81870549).

Publisher Copyright:
© 2019 Elsevier B.V.

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

Journal Article

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/j.diabres.2019.06.014

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Yang, W., Liu, J., Li, J., Liu, J., Liu, H., Wang, Y., Leng, J., Wang, S., Chen, H., Chan, J. C. N., Yu, Z., Hu, G., & Yang, X. (2019). Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China. Diabetes Research and Clinical Practice, 154, 82-89. https://doi.org/10.1016/j.diabres.2019.06.014

Yang, W, Liu, J, Li, J, Liu, J, Liu, H, Wang, Y, Leng, J, Wang, S, Chen, H, Chan, JCN, Yu, Z, Hu, G & Yang, X 2019, 'Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China', Diabetes Research and Clinical Practice, vol. 154, pp. 82-89. https://doi.org/10.1016/j.diabres.2019.06.014

@article{cb1e0a068e404a9b95772241b859f51b,

title = "Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China",

abstract = "Aims: Obesity increases risk of gestational diabetes mellitus (GDM) and GDM increases risk of macrosomia but their inter-relations for increased risk of macrosomia remain uncertain. We aimed to examine associations between prepregnancy overweight and macrosomia, and synergistic effects between prepregnancy overweight and GDM on macrosomia. Methods: From 2010 to 2012, 19,622 women in urban Tianjin, China, underwent a 50-g 1-h glucose challenge test (GCT) at 24–28 gestational weeks and followed by a 75-g 2-h oral glucose tolerance test (OGTT) if the GCT value was ≥ 7.8 mmol/L. GDM was defined according to International Association of Diabetes and Pregnancy Study Group's criteria. Overweight was defined as body mass index ≥ 24.0 kg/m2. Logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between prepregnancy overweight and GDM was used to test synergistic effects. Results: In the cohort, 1791 (9.1%) and 1726 (8.8%) of the women delivered a macrosomic infant or a large-for-gestational-age (LGA) infant, respectively. Prepregnancy overweight was associated with increased risk of macrosomia and LGA with adjusted ORs being 2.29 (95%CI: 2.07–2.54) and 2.27 (2.05–2.52), respectively. Copresence of prepregnancy overweight and GDM greatly enhanced the adjusted ORs of overweight alone (ORs for macrosomia and LGA: 2.17, 1.94–2.42 & 2.21,1.98–2.47) and GDM alone (ORs for macrosomia and LGA: 2.01,1.48–2.72 & 2.14, 1.60–2.87) for macrosomia and LGA to 5.29 (4.07–6.87) for macrosomia and 4.72 (3.66–6.10) for LGA, with significant additive interactions. Conclusions: Prepregnancy overweight increased the risks of macrosomia and LGA independently and synergistically with GDM.",

author = "Wen Yang and Jin Liu and Jing Li and Jinnan Liu and Hongyan Liu and Yue Wang and Junhong Leng and Shuo Wang and Huaxi Chen and Chan, {Juliana C.N.} and Zhijie Yu and Gang Hu and Xilin Yang",

note = "Funding Information: The authors would like to express our special thanks to obstetricians and other health professionals in the 64 primary care hospitals and 6 district women and children's health care institutes who were involved in the setting up of the cohort. X.Y. conceived and designed the study. W.Y. analyzed the data and wrote the first draft, J.L. H.L. Y.W. J.L. and S.W. provided the study material and patients, collected and assembly the data; All other authors gave critical comments on the manuscript; X.Y. (the corresponding authors) and W.Y. (the first author) take full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript. All authors have read and approved the submission of the manuscript; the manuscript has not been published and is not being considered for publication elsewhere, in whole or in part, in any language. This study was supported by the National Key Research and Development Program of China (Grant number: 2018YFC1313903) and National Natural Science Foundation of China (Grant number: 81870549). Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = aug,

doi = "10.1016/j.diabres.2019.06.014",

language = "English",

volume = "154",

pages = "82--89",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age

T2 - A population-based prospective cohort in Tianjin, China

AU - Yang, Wen

AU - Liu, Jin

AU - Li, Jing

AU - Liu, Jinnan

AU - Liu, Hongyan

AU - Wang, Yue

AU - Leng, Junhong

AU - Wang, Shuo

AU - Chen, Huaxi

AU - Chan, Juliana C.N.

AU - Yu, Zhijie

AU - Hu, Gang

AU - Yang, Xilin

N1 - Funding Information: The authors would like to express our special thanks to obstetricians and other health professionals in the 64 primary care hospitals and 6 district women and children's health care institutes who were involved in the setting up of the cohort. X.Y. conceived and designed the study. W.Y. analyzed the data and wrote the first draft, J.L. H.L. Y.W. J.L. and S.W. provided the study material and patients, collected and assembly the data; All other authors gave critical comments on the manuscript; X.Y. (the corresponding authors) and W.Y. (the first author) take full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript. All authors have read and approved the submission of the manuscript; the manuscript has not been published and is not being considered for publication elsewhere, in whole or in part, in any language. This study was supported by the National Key Research and Development Program of China (Grant number: 2018YFC1313903) and National Natural Science Foundation of China (Grant number: 81870549). Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/8

Y1 - 2019/8

N2 - Aims: Obesity increases risk of gestational diabetes mellitus (GDM) and GDM increases risk of macrosomia but their inter-relations for increased risk of macrosomia remain uncertain. We aimed to examine associations between prepregnancy overweight and macrosomia, and synergistic effects between prepregnancy overweight and GDM on macrosomia. Methods: From 2010 to 2012, 19,622 women in urban Tianjin, China, underwent a 50-g 1-h glucose challenge test (GCT) at 24–28 gestational weeks and followed by a 75-g 2-h oral glucose tolerance test (OGTT) if the GCT value was ≥ 7.8 mmol/L. GDM was defined according to International Association of Diabetes and Pregnancy Study Group's criteria. Overweight was defined as body mass index ≥ 24.0 kg/m2. Logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between prepregnancy overweight and GDM was used to test synergistic effects. Results: In the cohort, 1791 (9.1%) and 1726 (8.8%) of the women delivered a macrosomic infant or a large-for-gestational-age (LGA) infant, respectively. Prepregnancy overweight was associated with increased risk of macrosomia and LGA with adjusted ORs being 2.29 (95%CI: 2.07–2.54) and 2.27 (2.05–2.52), respectively. Copresence of prepregnancy overweight and GDM greatly enhanced the adjusted ORs of overweight alone (ORs for macrosomia and LGA: 2.17, 1.94–2.42 & 2.21,1.98–2.47) and GDM alone (ORs for macrosomia and LGA: 2.01,1.48–2.72 & 2.14, 1.60–2.87) for macrosomia and LGA to 5.29 (4.07–6.87) for macrosomia and 4.72 (3.66–6.10) for LGA, with significant additive interactions. Conclusions: Prepregnancy overweight increased the risks of macrosomia and LGA independently and synergistically with GDM.

AB - Aims: Obesity increases risk of gestational diabetes mellitus (GDM) and GDM increases risk of macrosomia but their inter-relations for increased risk of macrosomia remain uncertain. We aimed to examine associations between prepregnancy overweight and macrosomia, and synergistic effects between prepregnancy overweight and GDM on macrosomia. Methods: From 2010 to 2012, 19,622 women in urban Tianjin, China, underwent a 50-g 1-h glucose challenge test (GCT) at 24–28 gestational weeks and followed by a 75-g 2-h oral glucose tolerance test (OGTT) if the GCT value was ≥ 7.8 mmol/L. GDM was defined according to International Association of Diabetes and Pregnancy Study Group's criteria. Overweight was defined as body mass index ≥ 24.0 kg/m2. Logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between prepregnancy overweight and GDM was used to test synergistic effects. Results: In the cohort, 1791 (9.1%) and 1726 (8.8%) of the women delivered a macrosomic infant or a large-for-gestational-age (LGA) infant, respectively. Prepregnancy overweight was associated with increased risk of macrosomia and LGA with adjusted ORs being 2.29 (95%CI: 2.07–2.54) and 2.27 (2.05–2.52), respectively. Copresence of prepregnancy overweight and GDM greatly enhanced the adjusted ORs of overweight alone (ORs for macrosomia and LGA: 2.17, 1.94–2.42 & 2.21,1.98–2.47) and GDM alone (ORs for macrosomia and LGA: 2.01,1.48–2.72 & 2.14, 1.60–2.87) for macrosomia and LGA to 5.29 (4.07–6.87) for macrosomia and 4.72 (3.66–6.10) for LGA, with significant additive interactions. Conclusions: Prepregnancy overweight increased the risks of macrosomia and LGA independently and synergistically with GDM.

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JO - Diabetes Research and Clinical Practice

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ER -

Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

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