Introduction to genome biology and diversity

Noor Youssef, Aidan Budd, Joseph P. Bielawski

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9 Citations (Scopus)

Résumé

Organisms display astonishing levels of cell and molecular diversity, including genome size, shape, and architecture. In this chapter, we review how the genome can be viewed as both a structural and an informational unit of biological diversity and explicitly define our intended meaning of genetic information. A brief overview of the characteristic features of bacterial, archaeal, and eukaryotic cell types and viruses sets the stage for a review of the differences in organization, size, and packaging strategies of their genomes. We include a detailed review of genetic elements found outside the primary chromosomal structures, as these provide insights into how genomes are sometimes viewed as incomplete informational entities. Lastly, we reassess the definition of the genome in light of recent advancements in our understanding of the diversity of genomic structures and the mechanisms by which genetic information is expressed within the cell. Collectively, these topics comprise a good introduction to genome biology for the newcomer to the field and provide a valuable reference for those developing new statistical or computation methods in genomics. This review also prepares the reader for anticipated transformations in thinking as the field of genome biology progresses.

Langue d'origineEnglish
Titre de la publication principaleMethods in Molecular Biology
Maison d'éditionHumana Press Inc.
Pages3-31
Nombre de pages29
DOI
Statut de publicationPublished - 2019

Séries de publication

PrénomMethods in Molecular Biology
Volume1910
ISSN (imprimé)1064-3745
ISSN (électronique)1940-6029

Note bibliographique

Publisher Copyright:
© The Author(s) 2019.

ASJC Scopus Subject Areas

  • Molecular Biology
  • Genetics

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