Investigations regarding the utility of prodigiosenes to treat leukemia

Deborah A. Smithen; A. Michael Forrester; Dale P. Corkery; Graham Dellaire; Julie Colpitts; Sherri A. McFarland; Jason N. Berman; Alison Thompson

doi:10.1039/c2ob26535d

Investigations regarding the utility of prodigiosenes to treat leukemia

Deborah A. Smithen, A. Michael Forrester, Dale P. Corkery, Graham Dellaire, Julie Colpitts, Sherri A. McFarland, Jason N. Berman, Alison Thompson

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25 Citations (Scopus)

Résumé

Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

Langue d'origine	English
Pages (de-à)	62-68
Nombre de pages	7
Journal	Organic and Biomolecular Chemistry
Volume	11
Numéro de publication	1
DOI	https://doi.org/10.1039/c2ob26535d
Statut de publication	Published - janv. 7 2013

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1039/c2ob26535d

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abstract = "Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.",

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language = "English",

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AU - Smithen, Deborah A.

AU - Forrester, A. Michael

AU - Corkery, Dale P.

AU - Dellaire, Graham

AU - Colpitts, Julie

AU - McFarland, Sherri A.

AU - Berman, Jason N.

AU - Thompson, Alison

PY - 2013/1/7

Y1 - 2013/1/7

N2 - Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

AB - Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

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Investigations regarding the utility of prodigiosenes to treat leukemia

Résumé

ASJC Scopus Subject Areas

ODD de l’ONU

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