La S100B comme biomarqueur d’une perturbation de la barrière hémato-encéphalique après une réparation d’anévrisme aortique thoraco-abdominale: analyse secondaire d’une étude de cohorte prospective

Derek J. Roberts, Richard I. Hall, Yan Wang, Lisa C. Julien, Jeremy Wood, Kerry B. Goralski

Résultat de recherche: Articleexamen par les pairs

4 Citations (Scopus)

Résumé

Purpose: The objective of this study was to determine whether the magnitude of the peripheral inflammatory response to cardiovascular surgery is associated with increases in blood–brain barrier (BBB) permeability as reflected by changes in cerebrospinal fluid (CSF)/plasma S100B concentrations. Methods: We conducted a secondary analysis from a prospective cohort study of 35 patients undergoing elective thoracoabdominal aortic aneurysm repair with (n = 17) or without (n = 18) cardiopulmonary bypass (CPB). Plasma and CSF S100B, interleukin-6 (IL-6), and albumin concentrations were measured at baseline (C0) and serially for up to five days. Results: Following CPB, the median [interquartile range] plasma S100B concentration increased from 58 [32–88] pg·mL-1 at C0 to a maximum concentration (Cmax) of 1,131 [655–1,875] pg·mL-1 over a median time (tmax) of 6.3 [5.9–7.0] hr. In the non-CPB group, the median plasma S100B increased to a lesser extent. There was a delayed increase in CSF S100B to a median Cmax of 436 [406–922] pg·mL-1 in the CPB group at a tmax of 23.7 [18.5–40.2] hr. In the non-CPB group, the CSF concentrations were similar at all time points. In the CPB group, we did not detect significant correlations between plasma and CSF S100B with plasma IL-6 [r = 0.52 (95% confidence interval [CI], -0.061 to 0.84)] and CSF IL-6 [r = 0.53 (95% CI, -0.073 to 0.85)] concentrations, respectively. Correlations of plasma or CSF S100B levels with BBB permeability were not significant. Conclusion: The lack of parallel increases in plasma and CSF S100B following CPB indicates that S100B may not be a reliable biomarker for BBB disruption after thoracoabdominal aortic aneurysm repair employing CPB. Trial registration: www.clinicaltrials.gov (NCT00878371); registered 7 April 2009.

Titre traduit de la contributionS100B as a biomarker of blood–brain barrier disruption after thoracoabdominal aortic aneurysm repair: a secondary analysis from a prospective cohort study
Langue d'origineFrench
Pages (de-à)1756-1768
Nombre de pages13
JournalCanadian Journal of Anaesthesia
Volume68
Numéro de publication12
DOI
Statut de publicationPublished - déc. 2021

Note bibliographique

Funding Information:
Financial support for this investigation was provided by the Heart and Stroke Foundation of Canada (Nova Scotia Chapter), the Canadian Anesthesiologists’ Society, and the Dalhousie University Pharmacy Endowment Fund.

Publisher Copyright:
© 2021, Canadian Anesthesiologists' Society.

ASJC Scopus Subject Areas

  • Anesthesiology and Pain Medicine

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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