Liver biopsy complication rates in patients with non-alcoholic fatty liver disease

Felix Zhou, Ashley Stueck, Magnus McLeod

Résultat de recherche: Articleexamen par les pairs

1 Citation (Scopus)

Résumé

BACKGROUND: With new treatments for non-alcoholic fatty liver disease (NAFLD) on the horizon, it will be important to risk-stratify patients based on degree of fibrosis to allocate treatment to those at highest risk. No studies have examined the complication rates of liver biopsies in patients with NAFLD in the outpatient setting. METHODS: We conducted a retrospective chart review of all outpatient elective liver biopsies for NAFLD at a tertiary care centre over a 10-year period. Demographic variables and stage of fibrosis were recorded. Complications up to 1 week post-procedure were recorded. We used univariate logistic regression models to estimate the odds of major complications by fibrosis stage, age, sex, platelets, and international normalized ratio (INR). RESULTS: There were 582 biopsies reviewed in total. The mean age was 53 years. There was an even proportion of males to females. The mean fibrosis stage was 1.9; platelet count was 223.9, INR was 1, and partial thromboplastin time (PTT) was 31. Major complications occurred in 8 out of 582 biopsies (1.4%). Bleeding accounted for 6 of the major complications observed, while infection and pneumoperitoneum each occurred once. There were no statistically significant associations between age (odds ratio [OR] 0.97, 95% CI 0.92–1.03), female sex (OR 1.00, 95% CI 0.25–4.04), platelet count <150 (OR 0.59, 95% CI [-inf.], 3.86), INR >1.3 (OR 0.47, 95% CI 0.057– 3.85), fibrosis stage, and complication rate. CONCLUSIONS: Our results are consistent with previous studies examining complication rates in other patient populations and clinical settings and support the overall safety of liver biopsies.

Langue d'origineEnglish
Pages (de-à)106-112
Nombre de pages7
JournalCanadian Liver Journal
Volume5
Numéro de publication2
DOI
Statut de publicationPublished - mai 2022
Publié à l'externeOui

Note bibliographique

Publisher Copyright:
© 2022, University of Toronto Press. All rights reserved.

ASJC Scopus Subject Areas

  • Hepatology

PubMed: MeSH publication types

  • Journal Article

Empreinte numérique

Plonger dans les sujets de recherche 'Liver biopsy complication rates in patients with non-alcoholic fatty liver disease'. Ensemble, ils forment une empreinte numérique unique.

Citer