LncRNA-miRNA axes in breast cancer: Novel points of interaction for strategic attack

Jaganathan Venkatesh, Marie Claire D. Wasson, Justin M. Brown, Wasundara Fernando, Paola Marcato

Résultat de recherche: Short surveyexamen par les pairs

129 Citations (Scopus)

Résumé

Therapeutic effectiveness in breast cancer can be limited by the underlying mechanisms of pathogenesis, including epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and drug resistance. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are master regulators of gene expression and are functionally important mediators in these mechanisms of pathogenesis. Intricate crosstalks between these non-coding RNAs form complex regulatory networks of post-transcriptional gene regulation. Depending on the specific lncRNA/miRNA interaction, the lncRNA-miRNA axis can have tumor suppressor or oncogenic effects, thus defining the lncRNA-miRNA axis is important for determining targetability. Herein, we summarize the current literature describing lncRNA-miRNA interactions that are critical in the molecular mechanisms that regulate EMT, CSCs and drug resistance in breast cancer. Further, we review both the well-studied and potential novel mechanisms of lncRNA-miRNA interactions in breast cancer.

Langue d'origineEnglish
Pages (de-à)81-88
Nombre de pages8
JournalCancer Letters
Volume509
DOI
Statut de publicationPublished - juill. 1 2021

Note bibliographique

Funding Information:
JV is supported by a PhD Fellowship for Breast Cancer Research provided through the Dalhousie Medical Research Foundation (DMRF) and by an operating grant to PM from the Canadian Institutes of Health Research (CIHR, PJT 162313). M-CDW and JMB are supported by Genomics in Medicine scholarships from the DMRF, Cancer Research Training Program (CRTP) scholarships funded through the Beatrice Hunter Cancer Research Institute (BHCRI) and the Terry Fox Research Institute , and Scotia Scholars Awards funded through Research Nova Scotia. MCDW is also supported by scholarship from Dalhousie University's Faculty of Medicine. WF is funded by the CIHR grant (PJT 162313) to PM. Fig. 1 was created with BioRender.com .

Publisher Copyright:
© 2021

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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