Résumé
Stimulation of human lymphocytes with concanavalin A (Con A) resulted in variable lymphokine responses as indicated by factors inhibiting macrophage migration (MIF) or stimulating macrophage migration (MStF), or resulted in negligible responses. These responses were consistent for a given individual when repeated after several months. MIF responses were observed more frequently than MStF responses in patients with renal failure who had demonstrable alloantibodies. MStF responses were statistically associated with the presence of HLA DR1 antigens in patients with renal failure and two separate groups of healthy individuals, while MIF responses were associated with DR7 in the three groups studied. There was no correlation between immunoglobulin allotypes and lymphokine responses. These results suggest that lymphokine responses to Con A are indicators of nonspecific immunological responsiveness and are influenced by genes associated with the major histocompatibility complex.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 368-377 |
| Nombre de pages | 10 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 32 |
| Numéro de publication | 3 |
| DOI | |
| Statut de publication | Published - sept. 1984 |
Note bibliographique
Funding Information:The authors thank Dr. R. Rajaraman for providing murine macrophages, Dr. M. Gorelick, Dr. J. Verrier-Jones, Ms. P. Houlihan, and Ms. L. Kennedy for assistance in obtaining blood samples, and Ms. Pat Godin and Ms. Roxy Pelham for secretarial assistance. This work was supported by the Kidney Foundation of Canada.
ASJC Scopus Subject Areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology
ODD de l’ONU
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