Lysophosphatidylcholine reversibly arrests pore expansion during syncytium formation mediated by diverse viral fusogens

Marta Ciechonska, Roy Duncan

Résultat de recherche: Articleexamen par les pairs

15 Citations (Scopus)

Résumé

Using lysophosphatidylcholine, a curvature-inducing lysolipid, we have isolated a reversible, "stalled pore" phenotype during syncytium formation induced by the p14 fusion-associated small transmembrane (FAST) protein and influenza virus hemagglutinin (HA) fusogens. This is the first evidence that lateral propagation of stable fusion pores leading to syncytiogenesis mediated by diverse viral fusogens is inhibited by promotion of positive membrane curvature in the outer leaflets of the lipid bilayer surrounding intercellular fusion pores.

Langue d'origineEnglish
Pages (de-à)6528-6531
Nombre de pages4
JournalJournal of Virology
Volume88
Numéro de publication11
DOI
Statut de publicationPublished - juin 2014

ASJC Scopus Subject Areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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