Mast cells and natural killer cells—a potentially critical interaction

Liliana Portales-Cervantes; Bassel Dawod; Jean S. Marshall

doi:10.3390/v11060514

Mast cells and natural killer cells—a potentially critical interaction

Liliana Portales-Cervantes, Bassel Dawod, Jean S. Marshall

Medicine

Résultat de recherche: Review article › examen par les pairs

17 Citations (Scopus)

Résumé

Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response including the killing of target cells without the need for priming. However, activated NK cells can show improved effector functions. Mast cells are also critical for early host defense against a variety of pathogens and are predominately located at mucosal surfaces and close to blood vessels. Our group has recently shown that virus-infected mast cells selectively recruit NK cells and positively modulate their functions through mechanisms dependent on soluble mediators, such as interferons. Here, we review the possible consequences of this interaction in both host defense and pathologies involving NK cell and mast cell activation.

Langue d'origine	English
Numéro d'article	514
Journal	Viruses
Volume	11
Numéro de publication	6
DOI	https://doi.org/10.3390/v11060514
Statut de publication	Published - juin 2019

Note bibliographique

Funding Information:
Funding: The authors’ research was supported by The Canadian Institutes for Health Research, award number MOP93517.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Infectious Diseases
Virology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Review

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.3390/v11060514

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abstract = "Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response including the killing of target cells without the need for priming. However, activated NK cells can show improved effector functions. Mast cells are also critical for early host defense against a variety of pathogens and are predominately located at mucosal surfaces and close to blood vessels. Our group has recently shown that virus-infected mast cells selectively recruit NK cells and positively modulate their functions through mechanisms dependent on soluble mediators, such as interferons. Here, we review the possible consequences of this interaction in both host defense and pathologies involving NK cell and mast cell activation.",

author = "Liliana Portales-Cervantes and Bassel Dawod and Marshall, {Jean S.}",

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AU - Dawod, Bassel

AU - Marshall, Jean S.

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N2 - Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response including the killing of target cells without the need for priming. However, activated NK cells can show improved effector functions. Mast cells are also critical for early host defense against a variety of pathogens and are predominately located at mucosal surfaces and close to blood vessels. Our group has recently shown that virus-infected mast cells selectively recruit NK cells and positively modulate their functions through mechanisms dependent on soluble mediators, such as interferons. Here, we review the possible consequences of this interaction in both host defense and pathologies involving NK cell and mast cell activation.

AB - Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response including the killing of target cells without the need for priming. However, activated NK cells can show improved effector functions. Mast cells are also critical for early host defense against a variety of pathogens and are predominately located at mucosal surfaces and close to blood vessels. Our group has recently shown that virus-infected mast cells selectively recruit NK cells and positively modulate their functions through mechanisms dependent on soluble mediators, such as interferons. Here, we review the possible consequences of this interaction in both host defense and pathologies involving NK cell and mast cell activation.

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JO - Viruses

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ER -

Mast cells and natural killer cells—a potentially critical interaction

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer