Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study

The Canadian Neonatal Follow-Up Network; on behalf of the Canadian Neonatal Network

doi:10.1038/s41372-019-0356-3

Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study

The Canadian Neonatal Follow-Up Network, on behalf of the Canadian Neonatal Network

Medicine

Résultat de recherche: Article › examen par les pairs

3 Citations (Scopus)

Résumé

Objective: To compare neurodevelopmental outcomes of preterm infants at 18–21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke. Study design: Preterm infants born at <29 weeks of gestation and evaluated at 18–21 months CA were included. Primary outcome was a composite outcome of death or neurodevelopmental impairment (NDI). Results: Of a total of 2760 infants, 699 met exclusion criteria. Of the remaining 2061 infants, 280 (13.6%) were exposed to maternal smoking and 1781 (86.4%) were not. The odds of the composite outcome of death or NDI (aOR 1.40; 95% CI: 1.03–1.91), NDI alone (aOR 1.43; 95% CI: 1.01–2.03), and Bayley-III motor score <85 (aOR 1.91; 95% CI: 1.31–2.81) were higher in exposed infants. Conclusions: Exposure to maternal smoking was associated with adverse composite outcome of death or NDI, NDI alone and lower motor scores at 18–21 months CA.

Langue d'origine	English
Pages (de-à)	791-799
Nombre de pages	9
Journal	Journal of Perinatology
Volume	39
Numéro de publication	6
DOI	https://doi.org/10.1038/s41372-019-0356-3
Statut de publication	Published - juin 1 2019

Note bibliographique

Funding Information:
Funding Organizational support was provided by the Maternal-Infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, ON, Canada. Neonatal follow-up data were supported by a team grant from the Canadian Institutes of Health Research (FRN87518) awarded to Dr. Shoo Lee, and in-kind support from Mount Sinai Hospital. Dr. Prakesh Shah holds an Applied Research Chair in Reproductive and Child Health Services and Policy Research awarded by the CIHR (APR-126340). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Publisher Copyright:
© 2019, Springer Nature America, Inc.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

PubMed: MeSH publication types

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Accès au document

10.1038/s41372-019-0356-3

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@article{34f838d05d2e48e69660cf218d09f3f6,

title = "Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study",

abstract = "Objective: To compare neurodevelopmental outcomes of preterm infants at 18–21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke. Study design: Preterm infants born at <29 weeks of gestation and evaluated at 18–21 months CA were included. Primary outcome was a composite outcome of death or neurodevelopmental impairment (NDI). Results: Of a total of 2760 infants, 699 met exclusion criteria. Of the remaining 2061 infants, 280 (13.6%) were exposed to maternal smoking and 1781 (86.4%) were not. The odds of the composite outcome of death or NDI (aOR 1.40; 95% CI: 1.03–1.91), NDI alone (aOR 1.43; 95% CI: 1.01–2.03), and Bayley-III motor score <85 (aOR 1.91; 95% CI: 1.31–2.81) were higher in exposed infants. Conclusions: Exposure to maternal smoking was associated with adverse composite outcome of death or NDI, NDI alone and lower motor scores at 18–21 months CA.",

author = "{The Canadian Neonatal Follow-Up Network} and {on behalf of the Canadian Neonatal Network} and Krystyna Ediger and Hasan, {Shabih U.} and Anne Synnes and Jyotsna Shah and Dianne Creighton and Tetsuya Isayama and Shah, {Prakesh S.} and Abhay Lodha and Adele Harrison and Joseph Ting and Zenon Cieslak and Rebecca Sherlock and Wendy Yee and Khalid Aziz and Jennifer Toye and Carlos Fajardo and Zarin Kalapesi and Koravangattu Sankaran and Sibasis Daspal and Mary Seshia and Ruben Alvaro and Amit Mukerji and {Da Silva}, Orlando and Chuks Nwaesei and Lee, {Kyong Soon} and Michael Dunn and Brigitte Lemyre and Kimberly Dow and Victoria Bizgu and Keith Barrington and Christine Drolet and Bruno Piedboeuf and Martine Claveau and Marc Beltempo and Valerie Bertelle and Edith Masse and Roderick Canning and Hala Makary and Cecil Ojah and Luis Monterrosa and Akhil Deshpandey and Jehier Afifi and Andrzej Kajetanowicz and Lee, {Shoo K.} and Thevanisha Pillay and Reg Sauv{\'e} and Amber Reichert and Jaya Bodani and Koravangattu Sankaran and Diane Moddemann",

note = "Funding Information: Funding Organizational support was provided by the Maternal-Infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, ON, Canada. Neonatal follow-up data were supported by a team grant from the Canadian Institutes of Health Research (FRN87518) awarded to Dr. Shoo Lee, and in-kind support from Mount Sinai Hospital. Dr. Prakesh Shah holds an Applied Research Chair in Reproductive and Child Health Services and Policy Research awarded by the CIHR (APR-126340). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2019, Springer Nature America, Inc.",

year = "2019",

month = jun,

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doi = "10.1038/s41372-019-0356-3",

language = "English",

volume = "39",

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T1 - Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation

T2 - a multicenter cohort study

AU - The Canadian Neonatal Follow-Up Network

AU - on behalf of the Canadian Neonatal Network

AU - Ediger, Krystyna

AU - Hasan, Shabih U.

AU - Synnes, Anne

AU - Shah, Jyotsna

AU - Creighton, Dianne

AU - Isayama, Tetsuya

AU - Shah, Prakesh S.

AU - Lodha, Abhay

AU - Harrison, Adele

AU - Ting, Joseph

AU - Cieslak, Zenon

AU - Sherlock, Rebecca

AU - Yee, Wendy

AU - Aziz, Khalid

AU - Toye, Jennifer

AU - Fajardo, Carlos

AU - Kalapesi, Zarin

AU - Sankaran, Koravangattu

AU - Daspal, Sibasis

AU - Seshia, Mary

AU - Alvaro, Ruben

AU - Mukerji, Amit

AU - Da Silva, Orlando

AU - Nwaesei, Chuks

AU - Lee, Kyong Soon

AU - Dunn, Michael

AU - Lemyre, Brigitte

AU - Dow, Kimberly

AU - Bizgu, Victoria

AU - Barrington, Keith

AU - Drolet, Christine

AU - Piedboeuf, Bruno

AU - Claveau, Martine

AU - Beltempo, Marc

AU - Bertelle, Valerie

AU - Masse, Edith

AU - Canning, Roderick

AU - Makary, Hala

AU - Ojah, Cecil

AU - Monterrosa, Luis

AU - Deshpandey, Akhil

AU - Afifi, Jehier

AU - Kajetanowicz, Andrzej

AU - Lee, Shoo K.

AU - Pillay, Thevanisha

AU - Sauvé, Reg

AU - Reichert, Amber

AU - Bodani, Jaya

AU - Sankaran, Koravangattu

AU - Moddemann, Diane

N1 - Funding Information: Funding Organizational support was provided by the Maternal-Infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, ON, Canada. Neonatal follow-up data were supported by a team grant from the Canadian Institutes of Health Research (FRN87518) awarded to Dr. Shoo Lee, and in-kind support from Mount Sinai Hospital. Dr. Prakesh Shah holds an Applied Research Chair in Reproductive and Child Health Services and Policy Research awarded by the CIHR (APR-126340). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2019, Springer Nature America, Inc.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Objective: To compare neurodevelopmental outcomes of preterm infants at 18–21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke. Study design: Preterm infants born at <29 weeks of gestation and evaluated at 18–21 months CA were included. Primary outcome was a composite outcome of death or neurodevelopmental impairment (NDI). Results: Of a total of 2760 infants, 699 met exclusion criteria. Of the remaining 2061 infants, 280 (13.6%) were exposed to maternal smoking and 1781 (86.4%) were not. The odds of the composite outcome of death or NDI (aOR 1.40; 95% CI: 1.03–1.91), NDI alone (aOR 1.43; 95% CI: 1.01–2.03), and Bayley-III motor score <85 (aOR 1.91; 95% CI: 1.31–2.81) were higher in exposed infants. Conclusions: Exposure to maternal smoking was associated with adverse composite outcome of death or NDI, NDI alone and lower motor scores at 18–21 months CA.

AB - Objective: To compare neurodevelopmental outcomes of preterm infants at 18–21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke. Study design: Preterm infants born at <29 weeks of gestation and evaluated at 18–21 months CA were included. Primary outcome was a composite outcome of death or neurodevelopmental impairment (NDI). Results: Of a total of 2760 infants, 699 met exclusion criteria. Of the remaining 2061 infants, 280 (13.6%) were exposed to maternal smoking and 1781 (86.4%) were not. The odds of the composite outcome of death or NDI (aOR 1.40; 95% CI: 1.03–1.91), NDI alone (aOR 1.43; 95% CI: 1.01–2.03), and Bayley-III motor score <85 (aOR 1.91; 95% CI: 1.31–2.81) were higher in exposed infants. Conclusions: Exposure to maternal smoking was associated with adverse composite outcome of death or NDI, NDI alone and lower motor scores at 18–21 months CA.

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SN - 0743-8346

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SP - 791

EP - 799

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 6

ER -

Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer