Measurement of fluid ingress into calcium polyphosphate bioceramics using nuclear magnetic resonance microscopy

Joshua M. Bray; Carl Petrone; Mark Filiaggi; Steven D. Beyea

doi:10.1016/j.ssnmr.2007.10.003

Measurement of fluid ingress into calcium polyphosphate bioceramics using nuclear magnetic resonance microscopy

Joshua M. Bray, Carl Petrone, Mark Filiaggi, Steven D. Beyea

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

9 Citations (Scopus)

Résumé

A MR microscopy experiment is developed and used to characterize fluid ingress and microstructural transformation in degradable calcium polyphosphate (CPP) bioceramics. High-resolution (49 μm) maps of fluid density and spin-lattice relaxation rate were obtained as a function of time for CPP immersed in phosphate buffered saline. These results demonstrate clear differences in fluid transport rates and solid matrix microstructure in two differing CPP formulations. CPP has been proposed as a potential implantable device for the delivery of pharmaceuticals, and the magnetic resonance imaging (MRI) data are used in conjunction with previously reported bulk elution results to develop a hypothesis explaining microstructural evolution in these materials. This type of non-destructive evaluation of the structure-transport of fluids in CPP is important to improved design of these functionalized biomaterials for long-term, localized delivery of sustained levels of therapeutic agents. Crown

Langue d'origine	English
Pages (de-à)	118-128
Nombre de pages	11
Journal	Solid State Nuclear Magnetic Resonance
Volume	32
Numéro de publication	4
DOI	https://doi.org/10.1016/j.ssnmr.2007.10.003
Statut de publication	Published - déc. 2007

Note bibliographique

Funding Information:
This work was funded in part through the support of the NSERC Discovery program (SDB, MJF). The authors also acknowledge the support of the Canada Foundation for Innovation, NSERC, the Atlantic Innovation Fund, and other partners which fund the Facilities for Materials Characterization, managed by the Institute for Research in Materials. JMB acknowledges the support of a NRC Graduate Student Scholarship Supplement Award. We also wish to thank Gordie Hall (Dalhousie University), Ian Burton and Dr. John Walter (NRC-IMB) for their help on this project.

ASJC Scopus Subject Areas

Radiation
General Chemistry
Nuclear and High Energy Physics
Instrumentation

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abstract = "A MR microscopy experiment is developed and used to characterize fluid ingress and microstructural transformation in degradable calcium polyphosphate (CPP) bioceramics. High-resolution (49 μm) maps of fluid density and spin-lattice relaxation rate were obtained as a function of time for CPP immersed in phosphate buffered saline. These results demonstrate clear differences in fluid transport rates and solid matrix microstructure in two differing CPP formulations. CPP has been proposed as a potential implantable device for the delivery of pharmaceuticals, and the magnetic resonance imaging (MRI) data are used in conjunction with previously reported bulk elution results to develop a hypothesis explaining microstructural evolution in these materials. This type of non-destructive evaluation of the structure-transport of fluids in CPP is important to improved design of these functionalized biomaterials for long-term, localized delivery of sustained levels of therapeutic agents. Crown",

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AU - Beyea, Steven D.

N1 - Funding Information: This work was funded in part through the support of the NSERC Discovery program (SDB, MJF). The authors also acknowledge the support of the Canada Foundation for Innovation, NSERC, the Atlantic Innovation Fund, and other partners which fund the Facilities for Materials Characterization, managed by the Institute for Research in Materials. JMB acknowledges the support of a NRC Graduate Student Scholarship Supplement Award. We also wish to thank Gordie Hall (Dalhousie University), Ian Burton and Dr. John Walter (NRC-IMB) for their help on this project.

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AB - A MR microscopy experiment is developed and used to characterize fluid ingress and microstructural transformation in degradable calcium polyphosphate (CPP) bioceramics. High-resolution (49 μm) maps of fluid density and spin-lattice relaxation rate were obtained as a function of time for CPP immersed in phosphate buffered saline. These results demonstrate clear differences in fluid transport rates and solid matrix microstructure in two differing CPP formulations. CPP has been proposed as a potential implantable device for the delivery of pharmaceuticals, and the magnetic resonance imaging (MRI) data are used in conjunction with previously reported bulk elution results to develop a hypothesis explaining microstructural evolution in these materials. This type of non-destructive evaluation of the structure-transport of fluids in CPP is important to improved design of these functionalized biomaterials for long-term, localized delivery of sustained levels of therapeutic agents. Crown

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Measurement of fluid ingress into calcium polyphosphate bioceramics using nuclear magnetic resonance microscopy

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