Metabolomic analysis as biomarker to study steroid hormone administration in sepsis

C. Lehmann; N. Sharawy; J. Zhou; D. Pavlovic

doi:10.1016/j.mehy.2012.05.025

Metabolomic analysis as biomarker to study steroid hormone administration in sepsis

C. Lehmann, N. Sharawy, J. Zhou, D. Pavlovic

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

4 Citations (Scopus)

Résumé

Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metabolic profile (metabolomic fingerprint) can be used to study and guide steroid hormone administration in sepsis. Potential biomarker candidates are sphingomyelines and phosphatidylcholines.

Langue d'origine	English
Pages (de-à)	329-330
Nombre de pages	2
Journal	Medical Hypotheses
Volume	79
Numéro de publication	3
DOI	https://doi.org/10.1016/j.mehy.2012.05.025
Statut de publication	Published - sept. 2012

ASJC Scopus Subject Areas

General Medicine

PubMed: MeSH publication types

Journal Article

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10.1016/j.mehy.2012.05.025

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abstract = "Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metabolic profile (metabolomic fingerprint) can be used to study and guide steroid hormone administration in sepsis. Potential biomarker candidates are sphingomyelines and phosphatidylcholines.",

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AU - Pavlovic, D.

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AB - Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metabolic profile (metabolomic fingerprint) can be used to study and guide steroid hormone administration in sepsis. Potential biomarker candidates are sphingomyelines and phosphatidylcholines.

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Metabolomic analysis as biomarker to study steroid hormone administration in sepsis

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

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