Multiple sclerosis in childhood: Clinical profile in 125 patients

P. Duquette, T. J. Murray, J. Pleines, G. C. Ebers, D. Sadovnick, P. Weldon, S. Warren, D. W. Paty, A. Upton, W. Hader, R. Nelson, A. Auty, B. Neufeld, C. Meltzer

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340 Citations (Scopus)

Résumé

Multiple sclerosis (MS) has its usual onset in early adult life (average age of 30 years), but age at clinical onset varies considerably. The implications of the age of onset on the clinical presentation and course of MS are unclear. This population-based retrospective study presents data from a group of 125 patients with onset of MS before age 16 years and can thus be considered as representative of MS occurring in childhood. It demonstrates that childhood MS is more frequent in girls, that it very aften has a relapsing-remitting course, that initial bouts usually involve afferent structures of the central nervous system, that recovery from these is often complete, and that the pace of the disease is slow.

Langue d'origineEnglish
Pages (de-à)359-363
Nombre de pages5
JournalJournal of Pediatrics
Volume111
Numéro de publication3
DOI
Statut de publicationPublished - sept. 1987
Publié à l'externeOui

Note bibliographique

Funding Information:
Nine MS Clinics from the Canadian MS study group collaborated in this population-based retrospective Study. Each center completed questionnaires about various Supported in part by the Canadian Multiple Sclerosis Society. Submitted for publication Jan. 5, 1987; accepted April 7, 1987. Reprint requests: P. Duquette, MD, 1560 est rue Sherbrooke, Montreal, Quebec, Canada H2L 4K8.

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health

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