Résumé
The functional capacities of natural killer (NK) cells differ within and between individuals, reflecting considerable genetic variation. ‘Licensing/arming’ ‘disarming’ and ‘tuning’ are models that have been proposed to explain how interactions between MHC class I molecules and their cognate inhibitory receptors – Ly49 in mice and KIR in humans – ‘educate’ NK cells for variable reactivity and sensitivity to inhibition. In this review we discuss recent progress toward understanding the genetic, epigenetic, and molecular features that titrate NK effector function and inhibition, and the impact of variable NK cell education on human health and disease.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 222-239 |
| Nombre de pages | 18 |
| Journal | Trends in Immunology |
| Volume | 39 |
| Numéro de publication | 3 |
| DOI | |
| Statut de publication | Published - mars 2018 |
Note bibliographique
Funding Information:We apologize to researchers whose work could not be discussed here owing to space limitations. We thank Drs Joseph Sun and Jean-Benoît Le Luduec for helpful comments on the manuscript. This review was supported by a grant from the Banting Research Foundation , the Canadian Cancer Society , and the Canadian Institutes of Health Research Institute of Cancer Research (grant 705275 ) and the Beatrice Hunter Cancer Research Institute to J.E.B.; and by National Institutes of Health (NIH) grants AI125651 , HL129472 , CA23766 , AI069197 , AI123658 , and funding from the Leukemia and Lymphoma Society and Alex’s Lemonade Stand Foundation to K.C.H.
Publisher Copyright:
© 2018 Elsevier Ltd
ASJC Scopus Subject Areas
- Immunology and Allergy
- Immunology
ODD de l’ONU
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