Nectin 4 is the epithelial cell receptor for measles virus

Ryan S. Noyce; Christopher D. Richardson

doi:10.1016/j.tim.2012.05.006

Nectin 4 is the epithelial cell receptor for measles virus

Ryan S. Noyce, Christopher D. Richardson

Medicine

Résultat de recherche: Review article › examen par les pairs

107 Citations (Scopus)

Résumé

Measles virus (MV) causes acute respiratory disease, infects lymphocytes and multiple organs, and produces immune suppression leading to secondary infections. In rare instances it can also cause persistent infections in the brain and central nervous system. Vaccine and laboratory-adapted strains of MV use CD46 as a receptor, whereas wild-type strains of MV (wtMV) cannot. Both vaccine and wtMV strains infect lymphocytes, monocytes, and dendritic cells (DCs) using the signaling lymphocyte activation molecule (CD150/SLAM). In addition, MV can infect the airway epithelial cells of the host. Nectin 4 (PVRL4) was recently identified as the epithelial cell receptor for MV. Coupled with recent observations made in MV-infected macaques, this discovery has led to a new paradigm for how the virus accesses the respiratory tract and exits the host. Nectin 4 is also a tumor cell marker which is highly expressed on the apical surface of many adenocarcinoma cell lines, making it a potential target for MV oncolytic therapy.

Langue d'origine	English
Pages (de-à)	429-439
Nombre de pages	11
Journal	Trends in Microbiology
Volume	20
Numéro de publication	9
DOI	https://doi.org/10.1016/j.tim.2012.05.006
Statut de publication	Published - sept. 2012

Note bibliographique

Funding Information:
Work performed by the authors concerning the identification of Nectin 4/PVRL4 as the epithelial receptor for measles virus was supported by Canadian Institutes of Health Operating Grant (CIHR MOP 10638) and the Nova Scotia Health Research Foundation Health Research Grant (#1200). Additional funds were received from the Canadian Breast Cancer Foundation Atlantic Region Grant #2189 and the National Cancer Institute of Canada and Terry Fox Foundation Grant #16340. R.S.N. was supported by the Nova Scotia Health Research Foundation and held a trainee award from the Beatrice Hunter Cancer Research Institute with funds provided by the Terry Fox Foundation Strategic Health Research Training Program in Cancer Research at CIHR. C.D.R. is a Canada Research Chair (Tier I) in Vaccinology and Viral Therapeutics and received an equipment grant from the Canadian Foundation for Innovation.

ASJC Scopus Subject Areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/j.tim.2012.05.006

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title = "Nectin 4 is the epithelial cell receptor for measles virus",

abstract = "Measles virus (MV) causes acute respiratory disease, infects lymphocytes and multiple organs, and produces immune suppression leading to secondary infections. In rare instances it can also cause persistent infections in the brain and central nervous system. Vaccine and laboratory-adapted strains of MV use CD46 as a receptor, whereas wild-type strains of MV (wtMV) cannot. Both vaccine and wtMV strains infect lymphocytes, monocytes, and dendritic cells (DCs) using the signaling lymphocyte activation molecule (CD150/SLAM). In addition, MV can infect the airway epithelial cells of the host. Nectin 4 (PVRL4) was recently identified as the epithelial cell receptor for MV. Coupled with recent observations made in MV-infected macaques, this discovery has led to a new paradigm for how the virus accesses the respiratory tract and exits the host. Nectin 4 is also a tumor cell marker which is highly expressed on the apical surface of many adenocarcinoma cell lines, making it a potential target for MV oncolytic therapy.",

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Nectin 4 is the epithelial cell receptor for measles virus

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

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