Neural Basis of Internal Attention in Adults with Pure and Comorbid ADHD

Halima Rafi, Ryan Murray, Farnaz Delavari, Nader Perroud, Patrik Vuilleumier, Martin Debbané, Camille Piguet

Résultat de recherche: Articleexamen par les pairs

1 Citation (Scopus)

Résumé

Objective: To examine whether putatively atypical neuronal activity during internal attention in ADHD yields insights into processes underlying emotion dysregulation. Methods: We used a word processing paradigm to assess neural activations in adults with ADHD (N = 46) compared to controls (N = 43). We measured effects of valence, applied partial-least squares correlation analysis to assess multivariate brainbehavior relationships and ran subgroup analyses to isolate results driven by pure ADHD (N = 18). Results: During internal attention, ADHD, compared to controls, have (1) increased activation in the right angular gyrus (rAG), which appears driven by pure, not comorbid, ADHD and (2) diminished activation in the insula and fronto-striatal circuitry. Diminished activations were driven by negatively-valenced internal attention and negatively correlated with increased affective lability within the ADHD group. Conclusion: Internal attention in ADHD is associated with increased rAG activation, possibly reflecting difficulty converging external and internal information, and diminished activation within emotion regulation circuitry.

Langue d'origineEnglish
JournalJournal of Attention Disorders
DOI
Statut de publicationAccepted/In press - 2023
Publié à l'externeOui

Note bibliographique

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Swiss National Center of Competence in Research; “Synapsy: the Synaptic Basis of Mental Diseases” fnanced by the Swiss National Science Foundation [Grant Number 51NF40-158776], as well as a grant of the Swiss National Science Foundation to J.M.A. [Grant Number 32003B_156914].

Publisher Copyright:
© The Author(s) 2023.

ASJC Scopus Subject Areas

  • Developmental and Educational Psychology
  • Clinical Psychology

PubMed: MeSH publication types

  • Journal Article

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